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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
ProteomicsRelative quantitative analysis of proteome based on iTRAQ/TMT
Relative quantitative analysis of proteome based on iTRAQ/TMT.
ORGANISM(S): Homo sapiens (Human) 
2026-08-18 | PXD054529 | Pride
Itraq/tmt Quantitative analysis 
ProteomicsEndogenous Sulfane Sulfur Mediates the Oxidative Stress Response Process in Pseudomonas aeruginosa
Sulfane sulfur species are increasingly recognized as integral cellular components involved in sig-naling pathways and cytoprotection against oxidative stress in mammals. While their production in bacteria has been extensively studied, their functional role in bacterial oxidative stress defense re-m...
ORGANISM(S): Pseudomonas Aeruginosa 
2026-05-09 | PXD078215 |
UnknownErratum: SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler.
Not available
S-EPMC4496933 | biostudies-literature
ProteomicsIntegrated Analysis of Proteomics and Metabolomics in Infantile Epileptic Spasms Syndrome
Objective: This study aims to investigate the pathogenic mechanisms of IESS, utilizing metabolomics and proteomics analyses to uncover potential biomarkers for the disease, thereby providing new insights for diagnostic and therapeutic strategies. Methods: Cerebrospinal fluid samples from 6 IESS pati...
ORGANISM(S): Homo Sapiens 
2024-12-23 | PXD059204 |
ProteomicsGated phosphorylated proteomics of LAIR1-overexpressed and LAIR1-control in GL261 cells
The total protein in GL261 cells was extracted, part of it was taken out for protein concentration determination and SDS-PAGE detection, and the other part was taken for trypsin digestion, peptide desalting, phosphorylation modification peptide enrichment and purification, and finally 4D-Labelfree d...
ORGANISM(S): Mus Musculus 
2023-06-13 | PXD042932 |
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