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GenomicsTranscription factor Achaete-Scute homologue 2 initiates T follicular helper cell development [ChIP-Seq]
In immune responses, activated T cells migrate to B cell follicles and develop to T follicular helper (Tfh) cells, a new subset of CD4+ T cells specialized in providing help to B lymphocytes in the induction of germinal centers 1-3. Although Bcl6 has been shown to be essential in Tfh cell function, ...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-52839 | biostudies-arrayexpress
MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
ProteomicsCo-immunoprecipitation followed by mass spectrometry (Co-IP/MS) data of HNRNPF.
The interacting proteins of HNRNPF were identified in mouse embryonic stem cells by co-immunoprecipitation followed by mass spectrometry (Co-IP/MS).
ORGANISM(S): Mus musculus (Mouse) 
2025-06-30 | PXD065613 | Pride
Mesc Hnrnpf 
ProteomicsErk quantitative phosphorylation
To identify downstream phosphorylation substrates of Erk, we treated the iErk1; Erk KO cell line with and without doxycycline (DOX) for 48 hours. In the untreated group, intracellular Erk was found to be deficient. Mass spectrometry-based quantitative analysis was subsequently used to identify phosp...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-07 | PXD051508 | Pride
Mouse Erk 
TranscriptomicsTDP-43 regulates cancer-associated microRNAs
MicroRNAs (miRNAs) play important roles in a wide range of cellular processes. Aberrant regulation of miRNA genes contributes to human diseases, including cancer. The TAR DNA binding protein 43 (TDP-43), a DNA/RNA binding protein associated with neurodegeneration, is involved in miRNA biogenesis. He...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-85065 | biostudies-arrayexpress
MetabolomicsCroquemort elicits activation of the immune deficiency pathway in ticks
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain e...
2023-04-27 | MTBLS686 | MetaboLights
MetabolomicsSemen Cuscutae flavonoids activated the cAMP-PKA-CREB-BDNF pathway and exerted an antidepressant effect in mice

Background: Semen Cuscutae flavonoids (SCFs) constitute a class of metabolites of Semen Cuscutae, a botanical drug that was recently found to have an anti-depression effect. This study aimed to evaluate the anti-depression effects of SCFs in chronic unpredi...

2025-05-12 | MTBLS11688 | MetaboLights
GenomicsTet2-mediated DNA demethylation controls T cell cytokine expression [seq]
The conversion of 5-methylcytosine (5mC) into 5-Hydroxymethylcytosine (5hmC) by ten-eleven translocation (Tet) family has recently been identified as a key process for active DNA demethylation, whose effects in the immune response is currently unknown. Examination of both 5mC and 5hmC modifications ...
ORGANISM(S): Mus musculus 
2015-04-12 | E-GEOD-49139 | biostudies-arrayexpress
TranscriptomicsThe expression profiles of 82 novel and 245 known human imsRNAs
The expression profiling of 245 known and 82 novel imsRNAs (intermediate-size noncoding RNAs, 50-500nt, which were identified from human fetal brain tissue) across different human fetal tissues (brain, heart, liver, lung and spleen at the 24-week gestation stage), different fetal brain gestational s...
ORGANISM(S): Homo sapiens 
2010-12-21 | E-GEOD-26196 | biostudies-arrayexpress
MetabolomicsAnalysis of lipid nutrient differences in the milk of 13 species from a quantitative non-targeted lipidomics perspective

Lipid, an important organic component in milk, has health benefits for newborns. Profiles of milk lipid in multi-species from multi-level haven’t been accessible, therefore, we established a lipid subclass, lipid molecule, and fatty acid profile of 13 species to compare interspecific lipid differ...

2023-08-21 | MTBLS6767 | MetaboLights
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