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MetabolomicsCharacteristics of myocardial structure and central carbon metabolism during the early and compensatory stages of cardiac hypertrophy
Cardiac hypertrophy is a classical forerunner of heart failure and myocardial structural and metabolic remodeling are closely associated with cardiac hypertrophy. We aim to investigate the characteristics of myocardial structure and central carbon metabolism of cardiac hypertrophy at different stage...
2024-08-23 | MTBLS10555 | MetaboLights
ProteomicsDiscovery of Novel MLKL PROTAC Degrader for the Treatment of Hepatocellular Carcinoma via Promoting Parthanatos
Chen et al. discovered a highly potent and selective MLKL-targeted PROTAC C116 that effectively induces MLKL degradation and promotes parthanatos in HCC cells. More significantly, C116 was able to induce in vivo MLKL degradation and exerts anti-tumor activities in an orthotopic HCC tumor model, posi...
ORGANISM(S): Mus Musculus 
PXD069462 |
ProteomicsMouse hepatocyte-derived extracellular vesicle proteome analysis
Mouse hepatocyte AML12 cells were plated in T175 flasks until they reached >90% confluency after which spent medium was removed, and the cells were rinsed twice with Hanks Balanced Salt Solution (ThermoFisher, Waltham, MA, United States) prior to incubating them in serum-free medium overnight, follo...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD023860 | Pride
Extracellular vesicles Mouse hepatocytes Proteome 
ProteomicsFinding missing proteins from the epigenetically manipulated human cell with stringent quality criteria
There are three major epigenetic mechanisms, DNA methylation, histone modifications, and ncRNAs. The histone is a key player in epigenetics, and the acetylation and methylation are their most common post-translational modifications (PTMs). These histone modifications have important roles in transcri...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD002453 | Pride
Histone Chromosome-centric human proteome project Epigenetic Missing proteins 
ProteomicsGenetic mechanisms of cardiac sex diparities
Male and female disease states differ in their prevalence, treatment responses, and survival rates. In cardiac disease, women almost uniformly fare far worse than men1-3. Though sex plays a critical role in cardiac disease, the mechanisms underlying sex differences in cardiac homeostasis and disease...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD020139 | Pride
Mouse heart Sex disparities 
ProteomicsProteomic of control and FBL knockdown C4-2 cells
We employed a quantitative proteomics approach to compare the protein expression levels between control and FBL knockdown C4-2 cells, revealing expression levels of some proteins which have decreased mRNA half-life.
ORGANISM(S): Homo Sapiens 
2024-03-17 | PXD050701 |
ProteomicsPhosphoroteome of Scutellaria baicalensis
3289 phosphopeptides were identified and mapped to 1472 proteins that are comparable by phosphoproteomics analysis and annotated in COG/KOG, Domain, KEGG and GO database, respectively
ORGANISM(S): Scutellaria Baicalensis 
PXD041603 |
ProteomicsProteome of Scutellaria baicalensis Georgi
Proteome of Scutellaria baicalensis Georgi from multiple tissues
ORGANISM(S): Scutellaria Baicalensis 
PXD041602 |
ProteomicsA Hidden Human Proteome Encoded by the “Non-Coding” Genes
It has been a long debate whether the 98% “non-coding” fraction of human genome can encode functional proteins besides a “random noise” of translation. We used our established translatome sequencing (RNC-seq) to analyze human cells and found that up to 3330 long non-coding RNAs (lncRNAs) were bound ...
ORGANISM(S): Homo Sapiens 
2019-08-29 | PXD044056 |
ProteomicsMass Spectrometry analysis of potential proteins interacting with cyclin D1 mutants (T286A or T288A)
Co-IP assays and Proteomics were performed to identify potential E3 ligases interacted with both cyclin D1 T286A and cyclin D1 T288A.
ORGANISM(S): Homo Sapiens 
PXD052332 |
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