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ProteomicsPlasma proteomics analysis of inherited thrombocytopenia 2 patients
Inherited thrombocytopenia 2 (THC2) is difficult to diagnose due to the lack of specific clinical characteristics and diagnostic methods. To identify potential plasma protein biomarkers for THC2, we collected the plasma samples from THC2 patients, and analyzed the protein profiles using the liquid c...
ORGANISM(S): Homo Sapiens 
2021-03-22 | PXD024895 |
ProteomicsSENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
SENP1 deSUMOylates RIPK1 in TNF-R1 signaling complex (TNF-RSC), keeping RIPK1 in check. Loss of SENP1 leads to SUMOylation of RIPK1, which re-orchestrates TNF-RSC and modulates the ubiquitination patterns and activity of RIPK1.
ORGANISM(S): Mus Musculus 
2022-10-24 | PXD037648 |
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