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UnknownAR-V7 and resistance to enzalutamide and abiraterone in prostate cancer.
Not available
S-EPMC4201502 | biostudies-literature
TranscriptomicsMouse Models of Alveolar/Embryonal Rhabdomyosarcoma & Spindle Cell Sarcomas
A series of conditional mouse models of embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma and spindle cell sarcoma were generated and validated for relavence to corresponding human cancers. Conditional mouse models of embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma and spindle cell sarcoma...
ORGANISM(S): Mus musculus 
2011-02-17 | E-GEOD-22520 | biostudies-arrayexpress
TranscriptomicsThe Estrogen Receptor Co-Regulator Protein, Proline Glutamic Acid and Leucine Rich Protein 1 (PELP1) Mediates Estrogen Rapid Signaling and Neuroprotection in the Brain
We examined the role of PELP1 in E2-ER-mediated transcription in the hippocampus under conditions of GCI by perfroming global transcriptome analysis. E2-treated FLOX and PELP1 FBKO mice were subjected to GCI followed by 24 h reperfusion and the isolated RNA was utilized for RNA-seq analysis. Our res...
ORGANISM(S): Mus musculus 
2015-12-07 | E-GEOD-72136 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of prostate tumors with or without androgen receptor splice variant
Background. Androgen receptor splice variant-7 (AR-V7) is a truncated form of the androgen receptor protein which lacks the ligand-binding domain, the target of enzalutamide and abiraterone, but remains constitutively active as a transcription factor. We hypothesized that detection of AR-V7 in circ...
ORGANISM(S): Homo sapiens 
2014-09-03 | E-GEOD-56701 | biostudies-arrayexpress
TranscriptomicsAndrogen-Responsive microRNAs in mouse Sertoli Cells
Although decades of research have established that androgen is essential for spermatogenesis, androgen’s mechanism of action remains elusive. This is in part because only a few androgen-responsive genes have been definitively identified in the testis. Here, we report that microRNAs—small, noncoding ...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-37679 | biostudies-arrayexpress
TranscriptomicsShort-term rapamycin treatment in mice have few effects on the transcriptome of white adipose tissue compared to dietary restriction
Analysis of the transcriptome in the epididymal fat of young mice (8 months of age) from treatment of dietary restriction, or rapamycin Total RNA extracted from epididymal fat of 8 month old C57BL6/J mice started on ad libitum (AL) , 40% dietary restriction (DR), or 14 ppm rapamycin (Rapa) from 2 mo...
ORGANISM(S): Mus musculus 
2014-08-18 | E-GEOD-52825 | biostudies-arrayexpress
TranscriptomicsAstrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis
Double transgenic mice with hepatocyte-specific expression of AEG-1 and c-Myc show aggressive HCC compared to single transgenics. Gene expression was analyzed to understand the molecular mechanism by which AEG-1 and c-Myc cooperate to promote hepatocarcinogenesis. Livers were collected from naïve ad...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-61875 | biostudies-arrayexpress
TranscriptomicsThe effect of short term Rapamycin on the transcriptome of old mouse liver
Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin short term (6 months) Rapamycin from 19 months of age. Total RNA extracted from livers of 25 month old C57BL6/N male and female mice started on control or 14 ppm rapamycin (Rapa) from 19 months of ag...
ORGANISM(S): Mus musculus 
2014-02-07 | E-GEOD-48331 | biostudies-arrayexpress
TranscriptomicsThe effect of chronic Rapamycin on the transcriptome of old mouse liver
Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin chronically (21 months) from 4 months of age. Total RNA extracted from livers of 25 month old C57BL6/J male and female mice started on control or 14 ppm rapamycin (Rapa) from 4 months of age on 21 mo...
ORGANISM(S): Mus musculus 
2014-02-07 | E-GEOD-48333 | biostudies-arrayexpress
TranscriptomicsThe effect of Rapamycin on the transcriptome of old mouse liver
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-02-07 | E-GEOD-48334 | biostudies-arrayexpress
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