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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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The effect of Rapamycin on the transcriptome of old mouse liver

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Wilson Fok

PROVIDER: E-GEOD-48334 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.

Fok Wilson C WC Chen Yidong Y Bokov Alex A Zhang Yiqiang Y Salmon Adam B AB Diaz Vivian V Javors Martin M Wood William H WH Zhang Yongqing Y Becker Kevin G KG Pérez Viviana I VI Richardson Arlan A

PloS one 20140107 1

Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible for rapamycin's longevity effect, we analyzed the transcriptome of liver from 25-month-old male and female mice fed rapamycin starting at 4 months of age. Few changes (<300 transcripts) were observed in transcriptome of rapamy ...[more]

PMID: 24409289

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