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ProteomicsAmyotrophic Lateral Sclerosis-associated Mutants of SOD1 Modulate miRNA Biogenesis through Aberrant Interactions with Exportin 5
Mutations in SOD1 (Superoxide Dismutase 1) gene are associated with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. By employing ascorbate peroxidase (APEX)-based proximity labeling, coupled with LC-MS/MS analysis, we uncovered 37 and 28 proteins exhibiting higher abundance i...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-01-26 | PXD035452 | Pride
Lc-ms affinity purification sod1 apex 
ProteomicsMETTL1 Interacts with XPO5 to Modulate Pre-miRNA Export
tRNA methylguanosine methyltransferase 1 (METTL1) is the prominent m7G writer protein in yeast and human cells. While several studies documented the transcriptome-wide distributions of METTL1-installed m7G, very little is known about the protein-protein interactions (PPI) involving METTL1. To fill i...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD066690 | Pride
Affinity labeling Mirna Lc-msms 
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