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ProteomicsExtracellular matrix remodeling enhancing astrocyte lysosome pathway to reverse memory defected in Alzheimer’s disease
Extracellular matrix (ECM) remodeling is strongly linked to Alzheimer’s disease (AD) risk, but its functions are not fully understood. Here, we found that medial prefrontal cortex (mPFC) injection with chondroitinase ABC (ChABC) to remodel ECM reverses short-term memory loss and reduces Aβ depositio...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD046784 | Pride
Extracellular matrix remodeling Alzheimer's disease Astrocyte 
Proteomicsre-innervation muscle in nerve crush rats
Two simulated nerve injury models in the rat tibial nerve were compared: the nerve was either cut (denervated, DN group) or crushed but with the nerve sheath intact (re-innervated, RN group). The control group had a preserved and intact tibial nerve. As the high expression of Myh3, Postn, Col6a1 and...
ORGANISM(S): Rattus Rattus 
2022-04-06 | PXD033031 |
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