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MetabolomicsPu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions
Metabolic syndrome (MS) is a common metabolic disorder characterized by obesity, insulin resistance, cardiovascular disease and gut microbiota dysbiosis. Pu-erh tea and its ingredient theabrownin have known functions on the reduction of body weight gain and fat accumulation. However, few studies sys...
2024-09-25 | MTBLS2594 | MetaboLights
OtherIdentification of missing proteins defined by chromosome-centric proteome project in the cytoplasmic detergent-insoluble proteins
Data from ProteomeXchange, PXD ID: PXD001694. File: lungSILAC_first_14.mzml. Published as part of J Proteome Res. 2015 Jun 25 . From the Abstract: {{i}} ... As most samples prepared and analyzed in the C-HPP framework were focusing on detergent soluble proteins, we posit that as a natural compositi...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320016148 | GPMDB
Resource Reanalysis 
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
ProteomicsProteomics defines plasma biomarkers for the early diagnosis of biliary atresia
Early diagnosis of biliary atresia (BA) is crucial for improving the chances of survival and preserving the liver function of children with BA. To explore potential biomarkers for early diagnosis of BA with other non-BA jaundice cases, we performed proteomic analysis with data-independent acquisitio...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048938 | Pride
Machine learning Biliary atresia Dia Prm Plasma Cholestasis 
ProteomicsMass spectrometry based detergent-insoluble proteins of human cell lysates
The PXD project contains a project which aimed to identify protein evidences (missing proteins) from insoluble proteins from cell lysate by mass spectrometry. It involves the analysis of 3 human lung cell line and 3 liver cell lines,including the identification information and quantitative informa...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079997 | MassIVE
ProteomicstRNA-m1A Methylation Regulates the Infection of Magnaporthe oryzae by Supporting Ergosterol Biosynthesis
Ergosterols are essential components of fungal plasma membranes. Inhibitors targeting ergosterol biosynthesis (ERG) genes are critical for controlling fungal pathogens, including Magnaporthe oryzae, the fungus that causes rice blast. In this study we show that the Trm6/Trm61 complex catalyzes dynami...
ORGANISM(S): Pyricularia Oryzae 70-15 
2024-06-07 | PXD051352 |
MetabolomicsAdaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats

Bamboo rats (Rhizomys pruinosus) are among the few mammals that lives on a bamboo-based diet which is mainly composed of lignocellulose. However, the mechanisms of adaptation of their gut microbiome and metabolic systems in the degradation of lignocellulose are largely unknown. Here, we ...

2022-04-22 | MTBLS4161 | MetaboLights
ProteomicsProteomic analysis of UCHL1 conditional knockout mice
Proteomic analysis of osteoclast precursor cells of UCHL1 conditional knockout mice and wild-type mice was performed
ORGANISM(S): Mus Musculus 
2024-08-14 | PXD052578 |
ProteomicsMechanism behind microalgal self-flocculation
Self-flocculation driven by gravity has shown as promising microalgal harvesting technology due to no requirement for additives and energies. However, the inherent unclear mechanism impedes its efficiency enhancement and commercial application. Current researches most only focus on the protein and c...
ORGANISM(S): Chlorella Sp. 
2021-02-05 | PXD024007 |
ProteomicsMS assay of proteins after CO-IP with GPNMB antibody in hippocampus area
Three mice were excised at day 7 after pilocarpine treatment to induce abundant GPNMB expression (Figures 1 and 2). Hippocampal proteins were extracted and pulled down by anti-GPNMB immunoprecipitation for mass-spectrometer assay.
ORGANISM(S): Mus Musculus 
2025-07-21 | PXD066376 |
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