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ProteomicsIdentification of Cytosolic Protein Targets of Catechol Estrogens in Breast Cancer Cells Using a Click Chemistry-based Workflow
Catechol estrogens (CEs) are known to be toxic metabolites and the initiators in the oncogenesis of breast cancers via forming covalent adducts with DNAs. CEs shall also react with proteins but their cellular protein targets remain un-explored. Here we reported the identification of protein targets ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD017731 | Pride
Affinity purification Catechol estrogens Breast cancer cells Mass spectrometry Proteomic 
UnknownAnthropometric and lipid indices in relation to prediabetes and diabetes: A cross-sectional study in resource-limited areas of northwestern China.
Not available
S-EPMC12578674 | biostudies-literature
UnknownBuilding and refining protein models within cryo-electron microscopy density maps based on homology modeling and multiscale structure refinement.
Not available
S-EPMC2860449 | biostudies-literature
UnknownUtility of Anthropometric Indexes for Detecting Metabolic Syndrome in Resource-Limited Regions of Northwestern China: Cross-Sectional Study.
Not available
S-EPMC11622702 | biostudies-literature
ProteomicsIn-situ Click Reaction Coupled with Quantitative Proteomics for Identification of Protein Targets of Catechol Estrogens
Catechol estrogens (CEs) are metabolic electrophiles that actively undergo covalent interaction with cellular proteins, influencing molecular function. There is no feasible method to identify their binders in a living system. Herein, we developed a click chemistry-based approach using ethinylestradi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-28 | PXD009657 | Pride
Post translational modification Metabolites Proteomics Electrophiles Dimethyl labeling Lc/ms Catechol estrogens Oxidative stress Click chemistry Redox modification 
UnknownEfficacy and safety of insulin degludec/insulin aspart biosimilar B01711 vs originator insulin degludec/insulin aspart in Chinese patients with type 2 diabetes inadequately controlled on basal or premixed insulin: A multicenter, randomized, open-label, phase 3 study.
Not available
S-EPMC12757660 | biostudies-literature
MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
ProteomicsLiver tumor tissues extracted from a mouse model of hepatocellular carcinoma were subjected to proteomics
The highly metastatic MHCC-97H HCC cell line was orthotopic transplanted into the liver of nude mice to induce orthotopic tumor formation, and lung metastasis was observed. This experimental model not only reproduces the metastasis process of HCC in vivo, but also provides an important biological ma...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD059613 | Pride
UnknownPrevalence and genetic diversity of Enterocytozoon bieneusi in sheep in China.
Not available
S-EPMC6233543 | biostudies-literature
GenomicsChIP-Seq of OCT4, NANOG, p300 in 3iL Human Embryonic Stem Cells
Human embryonic stem cells (hESCs) are isolated from the inner cell mass of the blastocysts. The pluripotent properties of hESCs enable the derivation of cell-types or tissues of different lineages for potential applications such as therapeutics discovery and regenerative medicine. Even though hES...
ORGANISM(S): Homo sapiens 
2013-12-05 | E-MTAB-2044 | biostudies-arrayexpress
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