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GenomicsA role for H3K4 mono-methylation in facultative heterochromatin assembly and partitioning of chromatin readers
Mono-methylation of lysine 4 on histone H3 (H3K4me1) is a well-established feature of enhancers and promoters, although its function is unknown. Remarkably, we find H3K4me1 at the promoter regions of conditionaly-repressed muscle and stimulus-dependent inflammatory response genes in myoblasts. Durin...
ORGANISM(S): Mus musculus 
2014-03-29 | E-GEOD-50590 | biostudies-arrayexpress
GenomicsGenome-wide remodeling of the epigenetic landscape during myogenic differentiation
We have examined changes in the chromatin landscape during muscle differentiation by mapping the genome-wide location of ten key histone marks and transcription factors in mouse myoblasts and terminally differentiated myotubes, providing an exceptionally rich dataset that has enabled discovery of ke...
ORGANISM(S): Mus musculus 
2011-05-08 | E-GEOD-25308 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridsation of genomic DNA from a male and a female duck to the Roche NimbleGen chicken whole genome oligonucleotide array
Comparative genomic hybridsation of genomic DNA from a male and a female duck to the Roche NimbleGen chicken whole genome oligonucleotide array
ORGANISM(S): Anas platyrhynchos 
2010-02-09 | E-TABM-921 | biostudies-arrayexpress
UnknownTwo Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Not available
S-EPMC10794000 | biostudies-literature
GenomicsLoss of Tet enzymes compromises proper differentiation of embryonic stem cells
Tet enzymes (Tet1/2/3) catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and are dynamically expressed in various embryonic and adult cell types. While loss of individual Tet enzymes or combined deficiency of Tet1/2 allows for embryogenesis, the effect of complete ...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-55049 | biostudies-arrayexpress
GenomicsCombined deficiency of Tet1 and Tet2 is compatible with development but leads to epigenetic instability
Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet1 and Tet2 mediate 5hmC generation in mouse embryonic stem cells (ESCs) and various embryonic and adult tissues. To investigate the effects of combined deficiency of Tet1 and Tet2 on pluripotency and developm...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-42396 | biostudies-arrayexpress
UnknownDedifferentiation-derived neural stem cells exhibit perturbed temporal progression.
Not available
S-EPMC10240205 | biostudies-literature
UnknownDynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex.
Not available
S-EPMC4111230 | biostudies-literature
UnknownRapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex.
Not available
S-EPMC12602346 | biostudies-literature
TranscriptomicsPervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae
Protein-RNA interactions are integral components of nearly every aspect of biology including regulation of gene expression, assembly of cellular architectures, and pathogenesis of human diseases. However, studies in the past few decades have only uncovered a small fraction of the vast landscape of t...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-29 | E-GEOD-43747 | biostudies-arrayexpress
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