Sort   by:  
 Page size 
MetabolomicsLiver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma

Paraoxonase-1 (PON1) is specifically expressed in the liver and has crucial effects on various liver diseases. The functions and mechanisms underlying of PON1 in hepatocellular carcinoma (HCC) remain obscure. Here, we show that PON1 acts as a metabolic regulator to mitigate regulatory T (Treg) ce...

2025-09-07 | MTBLS12950 | MetaboLights
UnknownPre-existing humoral immunity and CD4+ T cell response correlate with cross-reactivity against SARS-CoV-2 Omicron subvariants after heterologous prime-boost vaccination.
Not available
S-EPMC10124102 | biostudies-literature
UnknownCX3CR1 deficiency-induced TIL tumor restriction as a novel addition for CAR-T design in solid malignancies.
Not available
S-EPMC10105289 | biostudies-literature
UnknownOdronextamab monotherapy in R/R DLBCL after progression with CAR T-cell therapy: primary analysis of the ELM-1 study.
Not available
S-EPMC12002204 | biostudies-literature
UnknownDurable remission related to CAR-T persistence in R/R B-ALL and long-term persistence potential of prime CAR-T.
Not available
S-EPMC10196916 | biostudies-literature
UnknownThe E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation.
Not available
S-EPMC7368286 | biostudies-literature
ProteomicsAn engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling
Insulin and insulin-like growth factors (IGF-1 and IGF-2) regulate metabolism, growth, and development via related receptors. In contexts such as brain function or fetal development, coordinated signaling by all three hormones is essential. We report the engineering of [GluB10, D-HisB24, GlyB31, Tyr...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD067251 | Pride
Neuroblastoma Sh-sy5y Insulin analog Human Lc-ms/ms 
TranscriptomicsMLL regulated genes in LSK/CD48- hematopoietic stem cells
The histone methyltransferase mixed lineage leukemia (MLL) is essential to maintain hematopoietic stem cells and is a leukemia protooncogene. Although Hox genes are well-characterized targets of MLL and MLL fusion oncoproteins, the range of Mll-regulated genes in normal hematopoietic cells remains u...
ORGANISM(S): Mus musculus 
2013-05-24 | E-GEOD-47205 | biostudies-arrayexpress
TranscriptomicsIntegrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype
Acute lymphoblastic leukemia (ALL), the commonest childhood malignancy, is characterized by recurring gross and submicroscopic structural genetic alterations that contribute to leukemogenesis. Disordered epigenetic regulation is a hallmark of many tumors, and while analysis of DNA methylation of lim...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-26281 | biostudies-arrayexpress
TranscriptomicsmiR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells
Administration of mesenchymal stem cells (MSCs) has the potential to ameliorate degenerative disorders and to repair damaged tissues. The homing of transplanted MSCs to injured sites is a critical property of engraftment. Our aim was to identify microRNAs involved in controlling MSC proliferation an...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-46989 | biostudies-arrayexpress
Sort   by:  
 Page size