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UnknownPre-existing humoral immunity and CD4+ T cell response correlate with cross-reactivity against SARS-CoV-2 Omicron subvariants after heterologous prime-boost vaccination.
Not available
S-EPMC10124102 | biostudies-literature
ProteomicsAn engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling
Insulin and insulin-like growth factors (IGF-1 and IGF-2) regulate metabolism, growth, and development via related receptors. In contexts such as brain function or fetal development, coordinated signaling by all three hormones is essential. We report the engineering of [GluB10, D-HisB24, GlyB31, Tyr...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD067251 | Pride
Neuroblastoma Sh-sy5y Insulin analog Human Lc-ms/ms 
TranscriptomicsmiR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells
Administration of mesenchymal stem cells (MSCs) has the potential to ameliorate degenerative disorders and to repair damaged tissues. The homing of transplanted MSCs to injured sites is a critical property of engraftment. Our aim was to identify microRNAs involved in controlling MSC proliferation an...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-46989 | biostudies-arrayexpress
UnknownBMX, a specific HDAC8 inhibitor, with TMZ for advanced CRC therapy: a novel synergic effect to elicit p53-, β-catenin- and MGMT-dependent apoptotic cell death.
Not available
S-EPMC9793577 | biostudies-literature
TranscriptomicsMLL regulated genes in LSK/CD48- hematopoietic stem cells
The histone methyltransferase mixed lineage leukemia (MLL) is essential to maintain hematopoietic stem cells and is a leukemia protooncogene. Although Hox genes are well-characterized targets of MLL and MLL fusion oncoproteins, the range of Mll-regulated genes in normal hematopoietic cells remains u...
ORGANISM(S): Mus musculus 
2013-05-24 | E-GEOD-47205 | biostudies-arrayexpress
ProteomicsAggregate-selective removal of pathological tau via clustering-activated degraders
Homotypic protein assembly is a critical mediator of biological function and disease state. Selective degradation of protein assemblies, while sparing monomeric forms, is required for interrogation of biological mechanisms and assembly-specific therapeutic intervention. We have exploited the require...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052957 | Pride
Neurodegenerative diseases Trim21 Tau 
UnknownCX3CR1 deficiency-induced TIL tumor restriction as a novel addition for CAR-T design in solid malignancies.
Not available
S-EPMC10105289 | biostudies-literature
UnknownUmbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2.
Not available
S-EPMC10304356 | biostudies-literature
TranscriptomicsTranscription profiling of human anaplastic large cell lymphoma cell lines - kinase signature
Anaplastic Large Cell Lymphomas (ALCL) represent a subset of lymphomas in which the Anaplastic Lymphoma Kinase (ALK) gene is frequently fused to the NPM gene. We previously demonstrated that the constitutive phosphorylation of ALK chimeric proteins is sufficient to induce cellular transformation in ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6184 | biostudies-arrayexpress
Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
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