Sort   by:  
 Page size 
TranscriptomicsMouse Segmental Duplication and Copy-Number Variation
Detailed analyses of the clone-based genome assembly reveal that the recent duplication content of mouse (4.94%) is now comparable to that of human (5.5%), in contrast to previous estimates from the whole-genome shotgun sequence assembly. The architecture of mouse and human genomes differ dramatical...
ORGANISM(S): Mus musculus 
2008-05-10 | E-GEOD-11369 | biostudies-arrayexpress
TranscriptomicsCanine CNVs associated with canFam2 segmental duplications
This study centered on using a custom made Nimblegen aCGH chip that targeted all segmental duplications in the canine genome to identify associated CNVs. A total of 19 hybridizations were performed in a panel of diverse dogs and a single wolf. Using computational approaches all segmental duplicat...
ORGANISM(S): Canis lupus familiaris 
2010-05-17 | E-GEOD-13266 | biostudies-arrayexpress
UnknownCombination of long-acting TRAIL and tumor cell-targeted photodynamic therapy as a novel strategy to overcome chemotherapeutic multidrug resistance and TRAIL resistance of colorectal cancer.
Not available
S-EPMC7977453 | biostudies-literature
UnknownIdentification of Novel Mutations in Chinese Infants With Citrullinemia.
Not available
S-EPMC8929347 | biostudies-literature
MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
ProteomicsSmall and large ribosomal subunit deficiencies lead to distinct gene expression signatures that reflect cellular growth rate
Levels of the ribosome, the conserved molecular machine that mediates translation, are tightly linked to cellular growth rate. In humans, ribosomopathies are diseases associated with cell-type-specific pathologies and reduced ribosomal protein (RP) levels. Because gene expression defects resulting f...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-10-12 | MSV000083033 | MassIVE
Proteomics,MultiomicsPervasive, coordinated protein level changes driven by transcript isoform switching during meiosis in yeast
To better understand the gene regulatory mechanisms that program developmental processes, we carried out simultaneous, genome-wide measurements of mRNA, translation and protein through meiotic differentiation in budding yeast.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-01-02 | MSV000081874 | MassIVE
TranscriptomicsINTER_specific hybs: A Burst of Segmental Duplications in the African Great Ape Ancestor
Wilson and King were among the first to recognize that the extent of phenotypic change between humans and great apes was dissonant with the rate of molecular change. Proteins are virtually identical; cytogenetically there are few rearrangements that distinguish ape-human chromosomes; rates of single...
ORGANISM(S): Pongo abelii 
2010-05-22 | E-GEOD-13884 | biostudies-arrayexpress
TranscriptomicsINTRA_specific hybs: A Burst of Segmental Duplications in the African Great Ape Ancestor
Wilson and King were among the first to recognize that the extent of phenotypic change between humans and great apes was dissonant with the rate of molecular change. Proteins are virtually identical; cytogenetically there are few rearrangements that distinguish ape-human chromosomes; rates of single...
ORGANISM(S): Pan troglodytes 
2010-05-22 | E-GEOD-13885 | biostudies-arrayexpress
TranscriptomicsFine-Scale Mapping and Sequencing of Structural Variation from Eight Human Genomes
Genetic variation amongst individual humans occurs on many different scales, ranging from gross alterations in the human karyotype to single-nucleotide changes. In this manuscript we explore variation on an intermediate scale-particularly insertions, deletions, and inversions affecting from a few t...
ORGANISM(S): Homo sapiens 
2008-05-01 | E-GEOD-10008 | biostudies-arrayexpress
Sort   by:  
 Page size