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ProteomicsKRAS mutation-selective requirement for ACSS2 in colorectal adenoma formation
Oncogenic KRAS mutations are prevalent in colorectal cancer (CRC) and are associated with poor prognosis and resistance to therapy. There is a substantial diversity of KRAS mutant alleles observed in CRC. Emerging clinical and experimental analysis of common KRAS mutations suggest that each mutation...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-02 | PXD050157 | Pride
Colorectal cancer Kras Acss2 
ProteomicsUnique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
RAC1P29S is the third most prevalent hotspot mutation in sun-exposed melanoma. RAC1 alterations in cancer are correlated with poor prognosis, resistance to standard chemotherapy, and insensitivity to targeted inhibitors. Although RAC1P29S mutations in melanoma and RAC1 alterations in several other c...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-18 | PXD046960 | Pride
Pd-1 Rac1 Melanoma Cdk9 
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