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TranscriptomicsMulti-component epigenetic control of pro-invasive genes in cancer cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-01-05 | E-GEOD-18899 | biostudies-arrayexpress
TranscriptomicsMulti-component epigenetic control of pro-invasive genes in cancer cells (miRNA)
To identify the epigenetic signature that controls cancer cell migration, we performed integrated gene expression, miRNA and epigenetic profiling of 486 selected invasion-associated genes in non-migratory MCF-7 breast carcinoma and highly migratory U251 glioma cells. We used a custom-built chromatin...
ORGANISM(S): Homo sapiens 
2010-01-05 | E-GEOD-18894 | biostudies-arrayexpress
TranscriptomicsProteolytic inactivation of the autoinhibitory prodomain is essential for the pro-tumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP)
Invasive cancers employ pericellular proteolysis to breach the extracellular matrix and basement membrane barriers and invade the surrounding tissue. Pro-invasive, pro-tumorigenic MT1-MMP is the primary mediator of proteolytic events on the cancer cell surface. Cellular MT1-MMP is synthesized as a l...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28655 | biostudies-arrayexpress
TranscriptomicsMulti-component epigenetic control of pro-invasive genes in cancer cells (ChIP-chip)
To identify the epigenetic signature that controls cancer cell migration, we performed integrated gene expression, miRNA and epigenetic profiling of 486 selected invasion-associated genes in non-migratory MCF-7 breast carcinoma and highly migratory U251 glioma cells. We used a custom-built chromatin...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-18890 | biostudies-arrayexpress
TranscriptomicsImmunodominant myelin basic protein fragments induce mechanical hypersensitivity.
An insulating myelin sheath ensures saltatory conduction of mechanosensory A afferents. Myelin damage results in the electrical instability of A fibers and the ability to generate pain in response to light touch/pressure (mechanical allodynia). We have hypothesized and then established that the re...
ORGANISM(S): Rattus norvegicus 
2012-03-03 | E-GEOD-34868 | biostudies-arrayexpress
TranscriptomicsMatrix metalloproteinase-9 and TIMP-1 in peripheral nerve: Implications for myelin formation
Remyelination is a key step in functional nerve regeneration performed by Schwann cells (SC). We have demonstrated that matrix metalloproteinase (MMP)-9 is a major regulator of signal transduction and phenotypic switching in SCs. Herein, genome-wide transcriptional profiling, followed by Ingenuity P...
ORGANISM(S): Mus musculus 
2012-02-28 | E-GEOD-33454 | biostudies-arrayexpress
TranscriptomicsS100 calcium-binding proteins A8/A9 initiate the early inflammatory program in injured peripheral nerve
To shed light on the early processes of immune response to peripheral nerve injury, we first used genome-wide transcriptional profiling and bioinformatics (Ingenuity, NextBio) pathway analyses of the proximal (P; regenerating) and distal (D; degenerating) nerve stumps at day 1 in the sciatic nerve a...
ORGANISM(S): Rattus norvegicus 
2015-01-01 | E-GEOD-62282 | biostudies-arrayexpress
UnknownA human coronavirus OC43-derived polypeptide causes neuropathic pain
Not available
S-SCDT-EMBOR-2021-54069V1 | biostudies-other
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