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TranscriptomicsGene expression profiling in heterophils with Salmonella enteritidis challenge using a chicken 44K Agilent microarray
To determine the transcriptional response to Salmonella enterica serovar Enteritidis (SE) infection, a newly developed chicken 44K Agilent array was used to analyze total RNA of heterophils from SE-resistant (line A) and SE–susceptible chickens (line B), treated with in vitro infection of SE (I) o...
ORGANISM(S): Gallus gallus 
2010-06-20 | E-GEOD-9416 | biostudies-arrayexpress
ProteomicsBovine Corpus Luteum Proteomics during Different Reproductive and Physiological Stages
Corpus luteum (CL) is an endocrine structure that undergoes substantial changes over short intervals during the bovine reproductive (estrous) cycle. These changes are regulated by a vast array of signaling molecules, mainly proteins, that govern reproduction. We collected a comprehensive set of CLs ...
ORGANISM(S): Bos taurus (Bovine) 
2026-02-19 | PXD069851 | Pride
ProteomicsExtracellular vesicles secreted by 3D tumor organoids are enriched for immune regulatory signaling biomolecules compared to conventional 2D glioblastoma cell systems
Background: Newer 3D culturing approaches are a promising way to better mimic the in vivo tumor microenvironment and to study the interactions between the heterogeneous cell populations of glioblastoma multiforme. Like many other tumors, glioblastoma uses extracellular vesicles as an intercellular c...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD047328 | Pride
Ev Extracellular vesicle Proteomics Microrna 3d organoid model Brain cancer Glioblastoma multiforme 
ProteomicsExtracellular Vesicle Proteomics in Staphylococcus aureus-Treated Blood and Sepsis Reveals Coordinated Acute Phase, Neutrophil, and Exocytosis Responses
Sepsis accounts for nearly 20% of global mortality, with antibiotic resistance worsening clinical outcomes. Rapid antibiotic administration and accurate pathogen identification remain crucial. It is well now known that extracellular vesicles (EVs) from human cells and bacterial membrane vesicles (bM...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2026-05-18 | PXD067303 | Pride
ProteomicsExtracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer
Background: Anaplastic thyroid cancer (ATC) is an aggressive and rare disease. Rapid metastasis and limited promising treatments call for additional therapeutic options, including drug repurposing. The early spreading of ATC highlights the importance of rapid therapy success assessment, which could ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD064007 | Pride
Anaplastic thyroid cancer Vandetanib Extracellular vesicles Dose-dependent transcriptomics and proteomics 
ProteomicsThe proteome of bacterial membrane vesicles in Escherichia coli - a time course comparison study in two different media
IntroductionBacteria inhabit the in- and outside of the human body, such as skin, gut or the oral cavity where they play an innoxious, beneficial or even pathogenic role. It is well known that bacteria can secrete membrane vesicles (MVs) like eukaryotic cells with extracellular vesicles (EVs). Sever...
ORGANISM(S): Escherichia coli 
2024-03-05 | PXD041301 | Pride
Proteomics Bmvs Functional assay 
ProteomicsBacterial extracellular vesicles as recyclable nutrient reservoirs
Bacterial extracellular vesicles (EVs) are known to mediate intercellular communication, virulence, and immune modulation. Here we show that bacteria can utilise EVs also as recyclable nutrient reservoirs. Using Bacillus cereus as a model organism, we demonstrate that EVs exhibit distinct dynamics d...
ORGANISM(S): Bacillus cereus AH187 
2026-02-17 | PXD065751 | Pride
TranscriptomicsGenome-Wide Gene Expression Profiling Of Chicken Spleen Responding To Campylobacter jejuni Infection In Broilers
Campylobacter jejuni (C. jejuni) is a zoonotic pathogen that causes human diarrhea worldwide. Chickens are a natural reservoir of C. jejuni. Understanding the host response to C. jejuni infection at the molecular level will lay the foundation to control human campylobacterosis by reducing food conta...
ORGANISM(S): Gallus gallus 
2011-01-01 | E-GEOD-18541 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in Salmonella Typhimurium stimulated heterophils using a chicken 44K Agilent microarray
To determine the host response to Salmonella Typhimurium (ST) in heterophils, a whole chicken genome array was used to analyze RNA isolated from heterophils stimulated in vitro with ST (30 min, 1 h, 2 h, and 3 h) or medium control (NS). Dual-color, direct comparisons were carried between ST-stimulat...
ORGANISM(S): Gallus gallus 
2010-04-13 | E-GEOD-14684 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in Salmonella Typhimurium encountered with heterophils
To study the pathogenicity of Salmonella Typhimurium (ST) in heterophils, a whole Salmonella genome array was used to analyze RNA isolated from Salmonella in vitro encountered with heterophils (30 min, 1 h, 2 h, and 3 h) or medium control (NS). Dual-color, direct comparisons were carried out between...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2011-01-01 | E-GEOD-16399 | biostudies-arrayexpress
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