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Since Usp11 encodes a DUB, we reasoned that Usp11 deficiency may lead to increased ubiquitination and destabilization of a protein that functions in neuronal differentiation and migration.To define the molecular mechanism of Usp11 deficiency on cortical development, we performed a label-free quantit...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-29 | PXD021587 | Pride
Using unbiased mass spectrometry-based screen to identify differences in ubiquitinated proteins in the overexpression of Usp11. To focus on potential substrates relevant for Usp11’s role in neurogenesis, we performed experiments with mouse embryonic stem (ES) cells, in which NPC and neurons are deri...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-29 | PXD021189 | Pride
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