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ProteomicsVersatile regulation of autophagy by the deubiquitinase USP11
Ubiquitination is a versatile post-translational modification known to regulate autophagy. Here, we show that loss of the deubiquitinase USP11 leads to an increase in the autophagic flux. To investigate the molecular details of how USP11 impacts autophagy, we determined interaction partners of USP11...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD022143 | Pride
Ubiquitination Autophagy Usp11 
ProteomicsUSP11 deubiquitinates monoubiquitinated SPRTN to repair DNA-protein crosslinks
DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with DNA metabolic processes such as replication, transcription, and recombination. SPRTN is a replication-coupled DNA-dependent metalloprotease that degrades proteins crosslinked to DNA to promote DPC repair. SPRTN function is tight...
ORGANISM(S): Homo sapiens (Human) 
2021-04-01 | PXD019923 | Pride
Deubiquitination Dpc Top1-ccs Dpc repair Monoubiquitinated sprtn Sprtn Usp11 
ProteomicsProteome for Usp11 knockout E17.5 cortex
Since Usp11 encodes a DUB, we reasoned that Usp11 deficiency may lead to increased ubiquitination and destabilization of a protein that functions in neuronal differentiation and migration.To define the molecular mechanism of Usp11 deficiency on cortical development, we performed a label-free quantit...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-29 | PXD021587 | Pride
Usp11 Cortex 
Proteomicsusp11 overexpression in neuron derived from mESCs for proteome and ubiquitylome analyses
Using unbiased mass spectrometry-based screen to identify differences in ubiquitinated proteins in the overexpression of Usp11. To focus on potential substrates relevant for Usp11’s role in neurogenesis, we performed experiments with mouse embryonic stem (ES) cells, in which NPC and neurons are deri...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-29 | PXD021189 | Pride
Mescs Ubiquitylome analyses Usp11 
GenomicsRNA-seq of KYSE410 cells expressing control, USP11 or ARID1A-targeting shRNAs
RNA-seq of KYSE410 cells expressing control, USP11 or ARID1A-targeting shRNAs
PRJNA547719 | ENA
GenomicsUSP11 promotes prostate cancer progression by upregulating AR and c-Myc activity [CUT&RUN]
USP11 promotes prostate cancer progression by upregulating AR and c-Myc activity [CUT&RUN]
PRJNA1115793 | ENA
GenomicsUSP11 promotes prostate cancer progression by upregulating AR and c-Myc activity [RNA-seq]
USP11 promotes prostate cancer progression by upregulating AR and c-Myc activity [RNA-seq]
PRJNA1114716 | ENA
GenomicsUSP11 promotes prostate cancer progression by upregulating AR and c-Myc activity [CUT&RUN]
Androgen receptor (AR) is a main driver for castration-resistant prostate cancer (CRPC). c-Myc is an oncogene underlying prostate tumorigenesis. Here we find that the deubiquitinase USP11 targets both AR and c-Myc in prostate cancer. USP11 expression was upregulated in metastatic prostate cancer and...
ORGANISM(S): Homo sapiens 
2024-07-13 | GSE268252 | GEO
TranscriptomicsUSP11 promotes prostate cancer progression by upregulating AR and c-Myc activity [RNA-seq]
Androgen receptor (AR) is a main driver for castration-resistant prostate cancer (CRPC). c-Myc is an oncogene underlying prostate tumorigenesis. Here we find that the deubiquitinase USP11 targets both AR and c-Myc in prostate cancer. USP11 expression was upregulated in metastatic prostate cancer and...
ORGANISM(S): Homo sapiens 
2024-07-13 | GSE268124 | GEO
TranscriptomicsRNA-seq of KYSE410 cells expressing control, USP11 or ARID1A-targeting shRNAs
We examined gene expression level in KYSE410 cells expressing control, USP11 or ARID1A-targeting shRNAs to study the mechanism underlying the tumor suppressive effect of ARID1A and USP11.
ORGANISM(S): Homo sapiens 
2019-11-30 | GSE132359 | GEO
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