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TranscriptomicsNEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors (RNA-Seq)
DNA topoisomerase 1 (Top1) inhibitors are mainstays of anticancer therapy. These drugs trap Top1 on DNA, stabilizing the Top1-cleavage complex (Top1-cc). The accumulation of Top1-ccs perturbs DNA replication fork progression, leading to DNA breaks and cell death. By analyzing the genomic occupancy a...
ORGANISM(S): Homo sapiens 
2022-11-04 | GSE212469 | GEO
GenomicsNEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors (ChIP-Seq)
DNA topoisomerase 1 (Top1) inhibitors are mainstays of anticancer therapy. These drugs trap Top1 on DNA, stabilizing the Top1-cleavage complex (Top1-cc). The accumulation of Top1-ccs perturbs DNA replication fork progression, leading to DNA breaks and cell death. By analyzing the genomic occupancy a...
ORGANISM(S): Homo sapiens 
2022-11-04 | GSE212468 | GEO
UnknownMechanisms controlling replication fork stalling and collapse at topoisomerase 1 cleavage complexes.
Not available
S-EPMC7617106 | biostudies-literature
UnknownNEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors.
Not available
S-EPMC9733930 | biostudies-literature
TranscriptomicsInvestigation of genetic compensation in tdp1-/- zebrafish embryos
Tdp1, tyrosyl-DNA phosphodiesterase 1, is an enzyme responsible for the repair of DNA breaks resulting from aberrant topoisomerase 1 activity, called Top1 cleavage complexes (Top1-CCs). Mutation of Tdp1 leads to a progressive neurodegenerative disorder spinocerebellar ataxia with axonal neuropathy 1...
ORGANISM(S): Danio rerio 
2022-04-19 | GSE148923 | GEO
GenomicsNEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors (ChIP-Seq)
NEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors (ChIP-Seq)
PRJNA875475 | ENA
GenomicsNEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors (RNA-Seq)
NEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors (RNA-Seq)
PRJNA875478 | ENA
UnknownFunctional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency.
Not available
S-EPMC4123100 | biostudies-literature
GenomicsInvestigation of genetic compensation in tdp1-/- zebrafish embryos
Investigation of genetic compensation in tdp1-/- zebrafish embryos
PRJNA626551 | ENA
ProteomicsUSP11 deubiquitinates monoubiquitinated SPRTN to repair DNA-protein crosslinks
DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with DNA metabolic processes such as replication, transcription, and recombination. SPRTN is a replication-coupled DNA-dependent metalloprotease that degrades proteins crosslinked to DNA to promote DPC repair. SPRTN function is tight...
ORGANISM(S): Homo sapiens (Human) 
2021-04-01 | PXD019923 | Pride
Deubiquitination Dpc Top1-ccs Dpc repair Monoubiquitinated sprtn Sprtn Usp11 
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