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Using a high-end mass spectrometry, we screened phosphoproteins and phosphopeptides in five types of Alzheimer's disease (AD) mouse models (5xFAD, APP-tg, PS1-tg, PS2-tg and APP-KI) and four types of frontotemporal lobar degeneration (FTLD) mouse models(CHMP2B-KI, PGRN-KI, VCP-KI and TDP43-KI) at m...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD027119 | Pride
Control of mRNA half-life is a powerful strategy to adjust individual mRNA levels to various stress conditions, because the mRNA degradation rate controls not only the steady-state mRNA level but also the transition speed of mRNA levels. Here, we analyzed mRNA half-life changes in response to cold s...
ORGANISM(S): Arabidopsis thaliana 
This SuperSeries is composed of the following subset Series: GSE27785: Gene expression profile of mouse hematopoietic stem cells GSE27786: Gene expression profile of mouse hematopoietic cells Refer to individual Series
ORGANISM(S): Mus musculus 
Mouse CD34(-)KSL hematopoietic stem cells and CD34(+)KSL multipotent progenitors were purified by cell sorting from bone marrow of 8-week-old C57BL/6 mice, and their gene expression was analyzed. Two biological replicates of CD34(-)KSL hematopoietic stem cells and CD34(+)KSL multipotent progenitors ...
ORGANISM(S): Mus musculus 
Each fraction of mouse hematopoietic cells was purified by cell sorting from bone marrow of 8-week-old C57BL/6 mice, and its gene expression was analyzed. Two biological replicates of each fraction were analyzed using a Mouse Genome 430 2.0 array (Affymetrix).
ORGANISM(S): Mus musculus 
We performed whole-exome sequencing of two Fanconi anemia patients without mutation of known FA genes, and identified a novel FA gene FANCT.
Key molecules that modulate the effect of dietary restriction (DR), a well-known laboratory intervention for longevity in organisms, remain elusive in mammals. We evaluated neuropeptide Y (Npy), which is involved in the physiological adaptation to energy deficits, for its role in the effects of DR. ...
ORGANISM(S): Mus musculus 
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