Chiglitazar - OmicsDI

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Unknown (19)
Metabolomics (4)
Genomics (4)
Transcriptomics (3)
Proteomics (2)

Organisms

Homo sapiens (4)
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EFO:0001352 (1)
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Human alphaherpesvirus 1 (1)
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Organisms

Homo sapiens (3)

Repository

MetaboLights (4)
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geo (3)
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pride (1)

Tissue

Blood plasma (1)

Technology Type

Mass spectrometry assay (3)
Mass spectrometry (1)
All-ion fragmentation (1)
Mass Spectrometry (1)
Shotgun proteomics (1)

Instrument Platform

Liquid Chromatography MS - positive - reverse-phase (2)
Liquid Chromatography MS - negative - reverse-phase (2)
Liquid Chromatography MS - positive - reverse phase (2)
Liquid Chromatography MS - negative - reverse phase (2)

Metabolite Name

(D-Pen2,D-Pen5)-Enkephalin (3)
(S)-3-Sulfonatolactate (3)
Samixogrel (3)
Desidustat (3)
Lupex (3)
Zilascorb (3)
Scleroglucan (3)
Mangiferol (2)
5,3',4'-Trihydroxy-3-methoxy-6,7-methylenedioxyflavone 4'-glucuronide (2)
2-[1-(2-Fluorophenyl)ethylamino]-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4-one (2)
Pentanamide, N-(cyanomethyl)-4-methyl-2-(((1S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)(1,1'-biphenyl)-4-yl)ethyl)amino)-, (2S)- (2)
3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one (2)
2-Methyl-1,1,4-trioxo-N-(2-pyridinyl)-3H-1$l^{6},2-benzothiazine-3-carboxamide (2)
(2R)-3-(4-Cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide (2)
1-Benzylisoquinoline (2)
Acetamido thiadiazole butyl sulfonamide (2)
Raluridine (2)
2-(4-Carboxy-3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)-2-methylpropanedioic acid (2)
Creatinine nitrite nitrate (2)
Epitheaflagallin 3-O-gallate (2)
4-[2-(3,4-Dihydro-6,7-dimethoxy-4-methyl-3-oxo-2-quinoxalinyl)ethyl]-3H-1,2,4-triazole-3,5(4H)-dione (2)
5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide (2)
3',6'-Diacetyloxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4-carboxylic acid (2)
5-Amino-4-(2-hydroxy-3,4-dimethoxyphenyl)-6-(7-imino-6-methoxy-5,8-dioxoquinolin-2-yl)-3-methylpyridine-2-carboxylic acid (2)
2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-((4-(trifluoromethyl)phenyl)methyl)benzamide (2)
2-Oxazolidinone, 3-[[(5-nitro-2-furanyl)methylene]amino]- (2)
3',6'-Dihydroxy-4,5-diaminospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one (2)
2-Amino-5-[[(2S)-1-[N-(carboxymethyl)-2,4-dinitroanilino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid (2)
Indole-3-acetyl-glycine (2)
Dioxidine (2)

First Public Date

2026 (3)
2024 (1)

Release Date

2025 (5)
2024 (5)
2023 (3)
2022 (1)
2020 (1)
2019 (1)
2017 (1)
2012 (1)
2006 (1)

Lab affiliation

Institute of Biophysics, Chinese Academy of Sciences (1)

Publication date

2026 (4)
2024 (2)
2025 (2)

Tags

xref:PubMed:39321217 (1)
xref:PubMed:41872189 (1)

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Plasma proteome profiling reveals the therapeutic effects of the PPAR pan-agonist chiglitazar on insulin sensitivity, lipid metabolism, and inflammation in type 2 diabetes

Chiglitazar is a novel peroxisome proliferator-activated receptor (PPAR) pan-agonist, which passed phase III clinical trials and was newly approved in China for use as an adjunct to diet and exercise in glycemic control in adult patients with Type 2 Diabetes (T2D). To explore the circulating protein...

ORGANISM(S): Homo sapiens (Human)

2024-01-26 | PXD039827 | Pride