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MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
ProteomicsDiscovery and identification of potential markers of Childhood Absence Epilepsy by MALDI imaging mass spectrometry
Top down identification of proteins detected by MALDI imaging. Childhood absence epilepsy is a prototypic form of generalized nonconvulsive epilepsy characterized by short impairments of consciousness concomitant with synchronous and bilateral spike-and-wave discharges in the electroencephalogram. F...
ORGANISM(S): Mus musculus (Mouse) 
2013-04-18 | PXD000009 | Pride
Maldi imaging Childhood absence epilepsy 
ProteomicsLocalized Proteomic Differences in Choroid Plexus of Alzheimers Disease and Epilepsy Patients
Alzheimers disease and epilepsy are reciprocally related. Among sporadic AD patients, seizures occur in 10-22 percent, and subclinical epileptiform abnormalities occur in 22-5 percent. Cognitive deficits, with prominent short-term memory impairments, occur in most epilepsy patients. Common neurophys...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-27 | MSV000091370 | MassIVE
UnknownPretreatment seizure semiology in childhood absence epilepsy.
Not available
S-EPMC5562968 | biostudies-literature
TranscriptomicsTemporal Cortex Control (mesial temporal lobe epilepsy control)
Ion channel splice array data from temporal cortex brain tissue samples collected from control subjects (no mesial temporal lobe epilepsy). Keywords: disease associated splicing changes Temporal cortex samples from control subjects were compared to temporal neocortex of patients with mesial temporal...
ORGANISM(S): Homo sapiens 
2007-01-23 | E-GEOD-6771 | biostudies-arrayexpress
UnknownPharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.
Not available
S-EPMC6171340 | biostudies-literature
ProteomicsProteomic profile of hippocampus regions from the pilocarpine medial temporal lobe epilepsy model
Label-free Proteomic profile of the dentate gyrus (dorsal and ventral) and CA3 (dorsal and ventral) microdissected from the hippocampus of the pilocarpine model of Mesial Temporal Lobe Epilepsy.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2024-03-25 | MSV000094401 | MassIVE
UnknownPretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy.
Not available
S-EPMC3806916 | biostudies-literature
UnknownPretreatment EEG in childhood absence epilepsy: associations with attention and treatment outcome.
Not available
S-EPMC3770172 | biostudies-literature
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