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MetabolomicsPolymicrobial detection and metabolomics in saliva of children with early childhood caries

Cariogenic microorganisms as well as salivary metabolic status in early childhood caries (ECC) have been reported to differ from that in adult caries. The main aim of this study was to identify specific microbial species and salivary metabolites in children with ECC using species-specific qPCR an...

2024-11-12 | MTBLS10890 | MetaboLights
TranscriptomicsTranscription profiling of human diagnostic samples from children with NCI high risk B-precursor ALL treated on the protocol COG 1961 to investigate early response and outcome in high-risk childhood acute lymphoblastic leukemia
The cure rate for childhood ALL has improved considerably in part because therapy is routinely tailored to the predicted risk of relapse. Various clinical and laboratory variables are used in current risk-stratification schemes, but many children who fail therapy lack adverse prognostic factors at i...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7440 | biostudies-arrayexpress
TranscriptomicsGlucocorticoid effect on mRNA translation in childhood acute lymphoblastic leukemia
Glucocorticoids (GCs) are a central component in treating childhood acute lymphoblastic leukemia (chALL). They mainly act via regulating gene transcription. However, control of mRNA translation by GC has never been assessed systematically. In our research, T- and precursor B-ALL cells were cultured ...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-48680 | biostudies-arrayexpress
TranscriptomicsRNA-seq of primary human bone marrow derived mesenchymal stromal cells from pediatric B-cell acute lymphoblastic leukemia (B-ALL) patients
To investigate the identity of the tumor microenvironment in acute lymphoblastic leukemia (B-ALL), the transcriptome of mesenchymal stromal cells derived from bone marrow of three pediatric patients at the onset of the disease was analyzed and compared with its normal counterpart.
ORGANISM(S): Homo sapiens 
2021-10-16 | E-MTAB-10838 | biostudies-arrayexpress
GenomicsCircRNAome of childhood B-ALL: Deciphering subtype-specific expression profiles and functional involvement
CircRNAome of childhood B-ALL: Deciphering subtype-specific expression profiles and functional involvement
PRJNA850185 | ENA
TranscriptomicsTranscription profiling of human ALL samples for patients included in the Dutch Childhood Oncology Group
Childhood acute lymphoblastic leukemia (ALL) comprises a large group of genetic subtypes with a favorable prognosis characterized by a TEL-AML1-fusion, hyperdiploidy (>50 chromosomes) or E2A-PBX1 fusion and a smaller group with unfavorable outcome characterized by either a BCR-ABL-fusion, MLL-rearr...
ORGANISM(S): Homo sapiens 
2009-02-01 | E-GEOD-13351 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human childhood B-lineage ALL patients reveals five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia
Background; The t(12;21)(p13;q22) translocation is found in 20 to 25% of cases of childhood B-lineage acute lymphoblastic leukemia (B-ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9170 | biostudies-arrayexpress
TranscriptomicsThe Methylome Landscape of Infant B-cell precursor Acute Lymphoblastic Leukemia (iB-ALL)
B-cell acute lymphoblastic leukemia (B-ALL) is the most prevailing childhood cancer. As predicated by its prenatal origin, infant B-ALL (iB-ALL) show a silent mutational landscape irrespective of the MLL rearrangement/status, suggesting that other regulatory mechanisms might be impaired in the conte...
ORGANISM(S): Homo sapiens 
2021-03-12 | E-MTAB-8505 | biostudies-arrayexpress
TranscriptomicsGenomic characterization implicates iAMP21 as a primary genetic event in childhood B-cell precursor acute lymphoblastic leukaemia
Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct subgroup of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) shown to have a dismal outcome on standard therapy. For improved diagnosis and prognosis of these patients, the initiating genetic events need to ...
ORGANISM(S): Homo sapiens 
2012-03-02 | E-GEOD-26192 | biostudies-arrayexpress
TranscriptomicsIntegration of high-resolution methylome and transcriptome analyses to dissect epigenomic changes in childhood acute lymphoblastic leukemia
B-cell precursor acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer. Although the genetic origin of the disease remains unclear, epigenetic modifications including DNA methylation are suggested to contribute significantly to leukemogenesis. We assessed the DNA methylation s...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-38235 | biostudies-arrayexpress
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