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ProteomicsHYDIN2 knockdown in NT2 cells analyses by LFQ
Segmental duplications at proximal loci can generate transcriptionally active chimeric pseudogenes (φgenes) by fusing contiguous sequences from two parental genes. These chimeric φgenes often co-opt 5′ regulatory elements for activation and acquire 3′ modifications that enhance transcript stability,...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD074698 | Pride
Hydin2 Chimeric pseudogene Lfq proteomics 
TranscriptomicsFunctional heritage: the evolution of chimeric RNA into a gene
Once believed to be unique features of neoplasia, chimeric RNAs have been discovered in normal physiology. We speculated that some chimeric RNAs may be functional precursors of genes and that forming chimeric RNA at the transcriptional level may be a “trial” mechanism before the functional element i...
ORGANISM(S): Homo sapiens Callithrix jacchus 
2020-01-22 | GSE130594 | GEO
GenomicsFunctional heritage: the evolution of chimeric RNA into a gene
Functional heritage: the evolution of chimeric RNA into a gene
PRJNA540701 | ENA
UnknownEmergence of a Chimeric Globin Pseudogene and Increased Hemoglobin Oxygen Affinity Underlie the Evolution of Aquatic Specializations in Sirenia.
Not available
S-EPMC6526914 | biostudies-literature
UnknownFunctional heritage: the evolution of chimeric RNA into a gene.
Not available
S-EPMC6948976 | biostudies-literature
UnknownA new CYP21A1P/CYP21A2 chimeric gene identified in an Italian woman suffering from classical congenital adrenal hyperplasia form.
Not available
S-EPMC2718876 | biostudies-literature
ProteomicsIP-MS Profiling of ANAPC1 and MP1 Interaction Networks in OVCAR3 Cells
We identified a pseudogene-derived chimeric transcript, vA-202, which encodes a partial ANAPC1-derived protein (MP1). To characterize its protein interaction network, we transiently expressed FLAG-tagged MP1 in OVCAR3 cells and performed immunoprecipitation using an anti-FLAG antibody. For compariso...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD070186 | Pride
Human Mp1 Anapc1 Ip-ms Ovarian cancer 
UnknownNovel deletion alleles carrying CYP21A1P/A2 chimeric genes in Brazilian patients with 21-hydroxylase deficiency.
Not available
S-EPMC3161346 | biostudies-literature
UnknownRNA ligation precedes the retrotransposition of U6/LINE-1 chimeric RNA.
Not available
S-EPMC6789731 | biostudies-literature
UnknownTripartite chimeric pseudogene from the genome of rice blast fungus Magnaporthe grisea suggests double template jumps during long interspersed nuclear element (LINE) reverse transcription.
Not available
S-EPMC2104539 | biostudies-literature
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