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TranscriptomicsGene expression profiling of xenografts and mouse embryonic fibroblasts with ectopically expressed PREX2 mutants
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-57311 | biostudies-arrayexpress
TranscriptomicsExpression data from melanoma xenograft tumors originating from primary immortalized melanocytes
PREX2 truncating mutations occur in melanoma. We used microarray based gene expression profiling to compare expression patterns between xenografts harboring control GFP, wt PREX2 or various human relevant PREX2 mutants Primary xenograft tumors derived from primary immortalized melanocytes expressing...
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-57309 | biostudies-arrayexpress
TranscriptomicsExpression data from Suv420h1 knockout and mutant PREX2 expressing MEFs (mouse embryonic fibroblasts)
PREX2 truncating mutations occur in melanoma. We used microarray based gene expression profiling to compare expression patterns between cells harboring Suv420h1 knockout and PREX2 mutant expressing Spontaneously immortalized MEFs from either wt or Suv420h1 knockout mice were used. Wt MEFs were trans...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-57310 | biostudies-arrayexpress
TranscriptomicsFoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Activated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3, and FoxO4, represent one of several effector arms of PI3K-AKT signaling, prompting geneti...
ORGANISM(S): Mus musculus 
2011-03-16 | E-GEOD-27932 | biostudies-arrayexpress
GenomicsEpigenetic profiling of well differentiated and dedifferentiated liposarcoma identifies H3K9me3 and Kruppel-like factor 6 (KLF6) as determinants of aggressiveness in sarcoma (ChIP-seq)
Little is known about the epigenomics of liposarcoma (LPS). Here, we profiled the global expression of 9 epigenetic marks in well differentiated (WD) and dedifferentiated (DD) LPS from 151 patients and found increased H3K9me3 among DDLPS tumors. We performed ChIP-seq and gene expression profiling ...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-57749 | biostudies-arrayexpress
TranscriptomicsEpigenetic profiling of well differentiated and dedifferentiated liposarcoma identifies H3K9me3 and Kruppel-like factor 6 (KLF6) as determinants of aggressiveness in sarcoma (expression)
Little is known about the epigenomics of liposarcoma (LPS). Here, we profiled the global expression of 9 epigenetic marks in well differentiated (WD) and dedifferentiated (DD) LPS from 151 patients and found increased H3K9me3 among DDLPS tumors. We performed ChIP-seq and gene expression profiling ...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-57750 | biostudies-arrayexpress
TranscriptomicsA comparison of DNA copy number profiling platforms using a panel of melanoma cell lines
The accurate mapping of recurring DNA copy number aberrations (CNAs), a hallmark feature of the cancer genome, has facilitated the discovery of tumor suppressor genes and oncogenes. Microarray-based assays designed to detect these chromosomal copy number alterations on a genome-wide and high-resolu...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-7822 | biostudies-arrayexpress
TranscriptomicsComparison of the genetic extinction of NRAS to pharmacological MEK inhibition in an inducible mouse model of melanoma
Since direct pharmacological inhibition of RAS has thus far been unsuccessful, we explored system biology approaches to identify synergistic drug combination(s) that can mimic direct RAS inhibition. Leveraging an inducible mouse model of NRAS-mutant melanoma, we compare pharmacological MEK inhibitio...
ORGANISM(S): Mus musculus 
2012-08-08 | E-GEOD-39984 | biostudies-arrayexpress
TranscriptomicsA timecourse analysis of the genetic extinction of NRAS in an inducible mouse model of melanoma.
We sought to understand the pathways involved in NRAS extinction over time using a doxycycline-dependent, inducible mouse model of melanoma. This data provides insights into the temporal dynamics of downstream NRAS signaling and helps to correlate differentially affected pathways. We used microarray...
ORGANISM(S): Mus musculus 
2012-08-08 | E-GEOD-39985 | biostudies-arrayexpress
TranscriptomicsOncogenic NRAS Signaling Differentially Regulates Survival and Proliferation in Melanoma.
This SuperSeries is composed of the following subset Series: GSE39984: Comparison of the genetic extinction of NRAS to pharmacological MEK inhibition in an inducible mouse model of melanoma [4 days post-treatment] GSE39985: A timecourse analysis of the genetic extinction of NRAS in an inducible mous...
ORGANISM(S): Mus musculus 
2012-08-08 | E-GEOD-39987 | biostudies-arrayexpress
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