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ProteomicsCharacterization of acrosin and acrosin binding protein as novel CRISP2 interacting proteins in boar spermatozoa
Previously we have reported that cysteine rich secretory protein 2 (CRISP2) is involved in high molecular weight complexes in boar spermatozoa under a native state. In the current study, CRISP2 interacting partners were identified using proteomic technology and their interaction was investigated und...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-03-09 | PXD037181 | Pride
Boar spermatozoa  protein complexes  colocalization  capacitation Interacting proteins 
ProteomicsShotgun proteomic analysis of embryonic axis of soybean seeds during germination under salt stress
Salinity is one of the main environmental stresses worldwide limiting soybean growth and yield. Seed imbibition and radical emergence are generally less affected by salinity in soybean. Towards unraveling the mechanisms underlying salt tolerance in soybean at germination stage, a comprehensive quant...
ORGANISM(S): Glycine max 
2015-04-07 | PXD001943 | Pride
Glycine max (l.) merrill Embryonic axis Gel-free proteomics Label-free quantification Salt tolerance Biomarkers 
ProteomicsHSF-1 promotes longevity through ubiquilin-1 dependent mitochondrial remodelling
Impaired protein homeostasis promotes age-associated tissue dysregulation, presenting a need for therapeutic approaches that can restore proteome integrity. The heat shock factor HSF-1 is the master transcriptional regulator of proteostasis and regulates the expression of heat shock proteins (HSPs),...
ORGANISM(S): Caenorhabditis elegans 
2024-10-17 | PXD044595 | Pride
Hsf-1  aging  proteomics 
ProteomicsComparative proteomic analysis and bioluminescent reporter gene assays to investigate effects of simulated microgravity on Caco-2 cells
Microgravity is one of the most important features in spaceflight. Previous evidence has shown that significant changes to the musculoskeletal and immune systems occurred under microgravity. The present study was undertaken to explore the change in protein abundance in human colon colorectal cells ...
ORGANISM(S): Homo sapiens (Human) 
2017-07-26 | PXD005823 | Pride
Simulated microgravity Nuclear factor κ-b Caco-2 cells Reporter gene technology Label-free proteomics Bioluminescence 
ProteomicsSubcellular fractionation of boar spermatozoa provides a novel view of the perinuclear theca proteome
The perinuclear theca (PT) is a highly condensed, largely insoluble protein structure that surrounds the nucleus of eutherian spermatozoa. While this structure is known to be important for fertilization, little is known regarding its proteomic composition. Recent reports have indicated that the PT u...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-03-09 | PXD030020 | Pride
Boar sperm Perinuclear theca proteome Head tail division 
ProteomicsMacrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV
We have designed and characterised antiviral PROteolysis TArgeting Chimeras (PROTACs) targeting the human protein cyclophilin A (CypA), a host cofactor for unrelated viruses including human immunodeficiency virus (HIV) and hepatitis C virus (HCV). The PROTAC warheads are based on fully synthetic mac...
ORGANISM(S): Homo sapiens (Human) 
2024-11-29 | PXD057024 | Pride
Proteomics Dia Hiv Protac 
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