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ProteomicsIntact HepG2 CHKA target engagement with CETSA
To confirm UNC638 and UNC737 target engagement to CHKA in live cells.
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD057925 | Pride
Cetsa Human Chka 
ProteomicsA CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation
CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.
ORGANISM(S): Homo Sapiens 
2026-03-03 | PXD075116 |
TranscriptomicsEffect of CHKA knockdown on C4-2 cell transcriptome
Analysis of C4-2 Prostate cancer cell line after 72 hours of knockdown. CHKA is overexpressed in a number of solid tumours, including prostate cancer. Results provide insight into the molecular mechanisms of CHKA in prostate carcinogenesis.
ORGANISM(S): Homo sapiens 
2015-11-18 | GSE63700 | GEO
TranscriptomicsCholine kinase alpha (CHKA) as a therapeutic target in pancreatic ductal adenocarcinoma: Expression, predictive value, and sensitivity to inhibitors
Choline kinase alpha (CHKA) plays a crucial role in the regulation of membrane phospholipid synthesis and has oncogenic properties in vitro. We have analyzed the expression of CHKA in cell lines derived from pancreatic ductal adenocarcinoma (PDAC) and have found increased CHKA expression and a good ...
ORGANISM(S): Homo sapiens 
2017-08-11 | GSE60321 | GEO
UnknownOverexpression of CHKA contributes to tumor progression and metastasis and predicts poor prognosis in colorectal carcinoma.
Not available
S-EPMC5341828 | biostudies-literature
UnknownMetabolic Stress-Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes-Associated Microvascular Dysfunction.
Not available
S-EPMC12412581 | biostudies-literature
UnknownBi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly.
Not available
S-EPMC9630884 | biostudies-literature
UnknownNeurodevelopmental disease-causing variants in choline kinase CHKA gene couple phosphatidylcholine synthesis to oxidative stress damage and disease etiology.
Not available
S-EPMC12800699 | biostudies-literature
GenomicsHomo sapiens
Effect of CHKA knockdown on C4-2 cell transcriptome
PRJNA268830 | ENA
UnknownChloroquine Suppresses Colorectal Cancer Progression via Targeting CHKA and PFKM to inhibit the PI3K/AKT Pathway and the Warburg Effect.
Not available
S-EPMC11844273 | biostudies-literature
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