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MetabolomicsHepatotoxicity and nephrotoxicity induced by the chlorpyrifos and chlorpyrifos-methyl metabolite, 3,5,6-trichloro-2-pyridinol, in orally exposed mice
3,5,6-Trichloro-2-pyridinol (TCP) is a primary degradation product of chlorpyrifos and chlorpyrifos-methyl. TCP has longer half-life in soil and greater solubility in water than its parent compound, and cause wide contamination in environments. However, studies about the toxic effects of TCP are lim...
2017-05-05 | MTBLS275 | MetaboLights
TranscriptomicsC. elegans : Control vs. Chlorpyrifos (0.5mg/ml) + Diazinon (1 mg/ml) treatment
Transcriptional profile of C. elegans comparing control vs. nematodes treated with 0.5 mg/ml of Chlorpyrifos and 1mg/ml of Diazinon (DZN) at 16°C. Toxicant was added to agar and nematode culture on petri dishes for 72h before harvesting. One condition experiment with six biological replicates in a d...
ORGANISM(S): Caenorhabditis elegans 
2010-07-22 | E-GEOD-16698 | biostudies-arrayexpress
TranscriptomicsC. elegans : Control vs.Chlorpyrifos and Diazinon treatments
This SuperSeries is composed of the following subset Series: GSE16686: C. elegans : Control vs. Diazinon (1 mg/ml) treatment GSE16688: C. elegans : Control vs. Chlorpyrifos (0.5mg/ml) treatment GSE16698: C. elegans : Control vs. Chlorpyrifos (0.5mg/ml) + Diazinon (1 mg/ml) treatment Refer to individ...
ORGANISM(S): Caenorhabditis elegans 
2010-07-22 | E-GEOD-16719 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fetal primary astrocytes treated with the insectisides Cyfluthrin and Chlorpyrifos
Given the widespread use of insecticides in the environment, it is important to perform studies evaluating their potential effects on humans. Organophosphate insecticides, such as chlorpyrifos, are being phased out; however, the use of pyrethroids in household pest control is increasing. While chlor...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-5023 | biostudies-arrayexpress
TranscriptomicsCerebellum from mice exposed to chronic low-level chlorpyrifos oxon
Chlorpyrifos (CPF) is an organophosphorus (OP) insecticide that is still widely used despite statutory restrictions on home use. CPF is converted to chlorpyrifos oxon (CPO) by oxidative desulfuration in liver. Paraoxonase (PON1) polymorphisms affects the catalytic efficiency of the hydrolysis of OP...
ORGANISM(S): Mus musculus 
2011-11-09 | E-GEOD-25250 | biostudies-arrayexpress
TranscriptomicsC. elegans : Control vs. Chlorpyrifos (0.5mg/ml) treatment
Transcriptional profile of C. elegans comparing control vs. nematodes treated with 0.5mg/ml of Chorpyrifos (CPF) at 16°C. Toxicant was added to agar and nematode culture on petri dishes for 72h before harvesting. One condition experiment with six biological replicates in a dye swap design.
ORGANISM(S): Caenorhabditis elegans 
2010-07-22 | E-GEOD-16688 | biostudies-arrayexpress
ProteomicsChlorpyrifos oxon crosslinking of amyloid beta 42 peptides is a new route for generation of self-aggregating amyloidogenic oligomers that promote Alzheimer’s disease
Epidemiological evidence suggests that people chronically exposed to organophosphorus pesticides are at increased risk of neurodegenerative disease. Covalently linked amyloid beta dimers have been isolated from the brains of Alzheimer’s patients. The toxic forms of amyloid beta are amyloid dimers ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-17 | PXD034163 | Pride
Chlorpyrifos oxon Amyloid beta Isopeptide Crosslinks 
TranscriptomicsC. elegans : Control vs. Chlorpyrifos and Diazinon treatments at 24oC
This SuperSeries is composed of the following subset Series: GSE24229: C. elegans : Control vs. Chlorpyrifos (0.5mg/l) treatment GSE24230: C. elegans : Control vs. Diazinon (0.5mg/l) treatment GSE24254: C. elegans : Control vs. Chorpyrifos (0.5mg/l) + Diazinon (1 mg/l) treatment Refer to individual ...
ORGANISM(S): Caenorhabditis elegans 
2011-07-31 | E-GEOD-24257 | biostudies-arrayexpress
TranscriptomicsTranscriptional impact of organophosphate and metal mixtures on olfaction: copper dominates the chlorpyrifos-induced response in adult zebrafish.
Chemical exposures in fish have been linked to loss of olfaction leading to an inability to detect predators and prey and decreased survival. However, the mechanisms underlying olfactory neurotoxicity are not well characterized, especially in environmental exposures which involve chemical mixtures. ...
ORGANISM(S): Danio rerio 
2013-05-21 | E-GEOD-47039 | biostudies-arrayexpress
TranscriptomicsRepeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects in maternal and fetal tissues
Chlorpyrifos oxon (CPO), the toxic metabolite of the organophosphorus (OP) insecticide chlorpyrifos, causes developmental neurotoxicity in humans and rodents. CPO is hydrolyzed by paraoxonase-1 (PON1), with protection determined by PON1 levels and the human Q192R polymorphism. To examine how the Q19...
ORGANISM(S): Mus musculus 
2014-08-04 | E-GEOD-58103 | biostudies-arrayexpress
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