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ProteomicsDiscovery of dehydroamino acids and their crosslinks in Alzheimer's Disease
Alzheimer’s disease is characterized by the accumulation of protein aggregates. Dehydroamino acids are rarely observed posttranslational modifications that contain an electrophilic alkene capable of forming protein-protein crosslinks, which may lead to protein aggregation. We used mass spectrometry-...
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD053814 | Pride
Crmp2 Alzheimer's disease Tau Gapdh Dehydroamino acids Crosslinks 
GenomicsTranslation-coupled sensing and degradation of RNA-protein crosslinks [Ribo-Seq: dataset_1]
Translation-coupled sensing and degradation of RNA-protein crosslinks [Ribo-Seq: dataset_1]
PRJNA906951 | ENA
GenomicsTranslation-coupled sensing and degradation of RNA-protein crosslinks [Ribo-Seq: dataset_2]
Translation-coupled sensing and degradation of RNA-protein crosslinks [Ribo-Seq: dataset_2]
PRJNA1002346 | ENA
GenomicsAtypical K6-linked ubiquitylation marks toxic RNA-protein crosslinks induced by formaldehyde
Atypical K6-linked ubiquitylation marks toxic RNA-protein crosslinks induced by formaldehyde
PRJNA933609 | ENA
ProteomicsIdentification of formaldehyde-induced DNA-protein crosslinks by PxP-MS
Compromised enzymatic actions, reactive metabolites, and various chemotherapeutics cause toxic covalent DNA-protein crosslinks (DPCs). Failure to repair DPCs results in genomic instability, premature aging, and tumorigenesis. However, understanding the principles underlying DPC formation and repair ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-20 | PXD026654 | Pride
Formaldehyde Pxp Dna-protein crosslinks Sprtn 
GenomicsReversible 5-formyluracil DNA-histone crosslinks: formation and biological effects
Reversible 5-formyluracil DNA-histone crosslinks: formation and biological effects
PRJNA551149 | ENA
ProteomicsTranslation-coupled sensing and degradation of RNA-protein crosslinks
Reactive aldehydes are abundant cytotoxic metabolites, which challenge homoeostasis by crosslinking cellular macromolecules. Whether RNA damage contributes to the toxicity of aldehydes and whether cells possess mechanisms to resolve RNA-protein crosslinks (RPCs) in particular is unknown. Studying th...
ORGANISM(S): Homo sapiens (Human) 
2023-11-13 | PXD038398 | Pride
Formaldehyde Rna-protein crosslinks Ups Rna damage Translational stress 
ProteomicsTranslation-coupled resolution of RNA-protein crosslinks
The aim of the measurements was to investigate RNA damage and RNA-protein crosslinks (RPC) formation in the context of aldehyde-induced toxicity. For this, a photoactivatable-ribonucleoside-enhanced crosslinking (PAR-CL) strategy using 4-thiouridine (4-SU) and UVA-radiation was used. The submitted d...
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD038332 | Pride
Rna-protein crosslinks 
ProteomicsDichlorvos-induced formation of isopeptide crosslinks between proteins in SH-SY5Y cells
Chlorpyrifos oxon catalyzes the crosslinking of proteins via an isopeptide bond between lysine and glutamic acid or aspartic acid in studies with purified proteins. Our goal was to determine the crosslinking activity of the organophosphorus pesticide, dichlorvos. We developed a protocol for examini...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD033593 | Pride
Shsy5y human neuroblastoma cells Dichlorvos Mass spectrometry Manual evaluation Protein prospector Crosslink Isopeptide Crosslinks 
OtherTranslation-coupled sensing and degradation of RNA-protein crosslinks [Ribo-Seq: dataset_2]
Reactive aldehydes are abundant cytotoxic metabolites, which challenge homoeostasis by crosslinking cellular macromolecules. Aldehyde-induced DNA-DNA crosslinks cause cancer and bone marrow failure in Fanconi anemia, while covalent DNA-protein crosslinks require proteolytic repair to prevent liver t...
ORGANISM(S): Homo sapiens 
2023-11-13 | GSE240135 | GEO
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