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TranscriptomicsCerebellum from mice exposed to chronic low-level chlorpyrifos oxon
Chlorpyrifos (CPF) is an organophosphorus (OP) insecticide that is still widely used despite statutory restrictions on home use. CPF is converted to chlorpyrifos oxon (CPO) by oxidative desulfuration in liver. Paraoxonase (PON1) polymorphisms affects the catalytic efficiency of the hydrolysis of OP...
ORGANISM(S): Mus musculus 
2011-11-09 | E-GEOD-25250 | biostudies-arrayexpress
ProteomicsChlorpyrifos oxon crosslinking of amyloid beta 42 peptides is a new route for generation of self-aggregating amyloidogenic oligomers that promote Alzheimer’s disease
Epidemiological evidence suggests that people chronically exposed to organophosphorus pesticides are at increased risk of neurodegenerative disease. Covalently linked amyloid beta dimers have been isolated from the brains of Alzheimer’s patients. The toxic forms of amyloid beta are amyloid dimers ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-17 | PXD034163 | Pride
Chlorpyrifos oxon Amyloid beta Isopeptide Crosslinks 
TranscriptomicsRepeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects in maternal and fetal tissues
Chlorpyrifos oxon (CPO), the toxic metabolite of the organophosphorus (OP) insecticide chlorpyrifos, causes developmental neurotoxicity in humans and rodents. CPO is hydrolyzed by paraoxonase-1 (PON1), with protection determined by PON1 levels and the human Q192R polymorphism. To examine how the Q19...
ORGANISM(S): Mus musculus 
2014-08-04 | E-GEOD-58103 | biostudies-arrayexpress
ProteomicsOrganophosphorus pesticides catalyze protein crosslinking
Exposure to organophosphorus pesticides (OP) can have chronic adverse effects that are independent of inhibition of acetylcholinesterase, the classic target for acute OP toxicity. In pure proteins, the organophosphorus pesticide chlorpyrifos oxon induces a crosslink between lysine and glutamate (or...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-10-14 | PXD034529 | Pride
Chlorpyrifos oxon Protein prospector Map-rich tubulin Isopeptide Crosslinks 
UnknownNanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity.
Not available
S-EPMC2753691 | biostudies-literature
TranscriptomicsCerebellum from mice exposed to chronic low-level chlorpyrifos oxon
Chlorpyrifos (CPF) is an organophosphorus (OP) insecticide that is still widely used despite statutory restrictions on home use. CPF is converted to chlorpyrifos oxon (CPO) by oxidative desulfuration in liver. Paraoxonase (PON1) polymorphisms affects the catalytic efficiency of the hydrolysis of OPs...
ORGANISM(S): Mus musculus 
2011-11-09 | GSE25250 | GEO
UnknownInhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by chlorpyrifos oxon, paraoxon and methyl paraoxon.
Not available
S-EPMC3345137 | biostudies-literature
UnknownComplementary biological and computational approaches identify distinct mechanisms of chlorpyrifos versus chlorpyrifos-oxon-induced dopaminergic neurotoxicity.
Not available
S-EPMC9887671 | biostudies-literature
UnknownNeurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon.
Not available
S-EPMC3367041 | biostudies-literature
UnknownChlorpyrifos Oxon Activates Glutamate and Lysine for Protein Cross-linking.
Not available
S-EPMC9846825 | biostudies-literature
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