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ProteomicsCHIP/CHN-1 and UFD-2 C. Elegans Proteomes
The E3 ubiquitin ligases CHIP/CHN-1 and UFD-2 team up to accelerate ubiquitin chain formation. However, it remained largely unclear how the high processivity of this E3 set is achieved. Here we studied the molecular mechanism and function of the CHN-1/UFD-2 complex in Caenorhabditis elegans. Our dat...
ORGANISM(S): Caenorhabditis elegans 
2022-05-04 | PXD028023 | Pride
Chn-1 Ufd-2 C. elegans Proteo Chip E3 
ProteomicsTMT-based quantitative proteomics to study CHN-1/HSP-1 complex substrate turnover in C. elegans
The wild type (WT) and HSP-1 EEYD (worms generating endogenously mutated HSP-1) C. elegans were cultured under normal conditions (20 degrees) or exposed to 30 degrees for 16 hours as L4 larvae (referred to as heat stress/HS). In WT worms undergoing HS, the activity of CHN-1 ubiquitin ligase is antic...
ORGANISM(S): Caenorhabditis elegans 
2024-11-08 | PXD048200 | Pride
E3 ligase/chaperone C. elegans Chn-1 (human ortholog chip) Hsp-1 (human ortholog hsp-70) 
GenomicsLactobacillus johnsonii 135-1-CHN
Reference genome for Human Microbiome Project
PRJNA42545 | ENA
ProteomicsCHN-1 and CHN-1 L141R interacting proteins
Proteostasis is achieved by quality control pathways that support the generation of correctly folded proteins, prevent protein misfolding and remove toxic proteins. The quality control E3 ligase CHIP ubiquitylates damaged proteins consigned by chaperone partners for disposal through the endo-lysosom...
ORGANISM(S): Caenorhabditis elegans 
2022-08-25 | PXD025375 | Pride
C.elegans Lc-ms/ms 
TranscriptomicsNeuregulin 1 type III reduces severity in a mouse model of Congenital Hypomyelination Neuropathy
Purpose: We hypothesised that neuregulin 1 type III would reverse CHN. Using a faithful mouse model of CHN, we rescued the myelination defects by activation of Nrg1 type III. Unexpectedly, rescue did not depend on upregulation of Egr2 or major myelin genes. Therefore we asked whether we could identi...
ORGANISM(S): Mus musculus 
2018-09-01 | GSE101808 | GEO
UnknownA heterotypic assembly mechanism regulates CHIP E3 ligase activity.
Not available
S-EPMC9340540 | biostudies-literature
UnknownHSP70 inhibits CHIP E3 ligase activity to maintain germline function in Caenorhabditis elegans.
Not available
S-EPMC11567022 | biostudies-literature
UnknownAntibody prevalence and immunotherapy response in Chinese patients with epilepsy and encephalopathy scores for patients with different neuronal surface antibodies.
Not available
S-EPMC8710347 | biostudies-literature
UnknownA Heterotypic Assembly Mechanism Regulates CHIP E3 Ligase Activity
Not available
S-SCDT-EMBOJ-2021-109566 | biostudies-other
UnknownIdentification of a novel picornavirus in healthy piglets and seroepidemiological evidence of its presence in humans.
Not available
S-EPMC3735577 | biostudies-literature
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