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A major challenge for lipidomic analyses is the handling of the large amounts of data and the translation of results to interpret the involvement of lipids in biological systems. We built a new lipid ontology (LION) that associates over 50,000 lipid species to biophysical, chemical and cell biologic...
2019-04-24 | MTBLS757 | MetaboLights
Based on the observation that arachidonic acid represses interferon beta induced transcriptional activation of hCXCL10, hIL12b and IDO1a in THP1 cells and MDMs within 3 h post treatment. This experiment was designed to find other transcripts effected in a similar fashion.
ORGANISM(S): Homo sapiens 
Hyperinsulinemia, often associated with obesity and type 2 diabetes mellitus, is also linked to an elevated risk of various cancers. However, the specific mechanisms underlying this connection remain unclear. Here, we report that inhibiting neddylation, in the presence of insulin treatment, further ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD044760 | Pride
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