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MetabolomicsWhat CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines

Background: Cell line specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such models have recently become available for Chinese hamster ovary (CHO) too. However, a key ingredient, namely an experimentally validat...

2020-07-13 | MTBLS1210 | MetaboLights
MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
TranscriptomicsCHO cells with enhanced and abolished gamma-secretase activity
γ-secretase is an intra-membrane-cleaving aspartyl protease implicated in the processing of a wide range of type I membrane proteins including the Notch receptor and the amyloid-β precursor protein (APP). It thus regulates a diverse array of cellular and biological processes including the differen...
ORGANISM(S): Cricetulus griseus 
2010-05-15 | E-GEOD-16379 | biostudies-arrayexpress
TranscriptomicsAnalysis of mature miRNA levels in the context of CHO cell proliferation
mature microRNA transcripts were analyzed in 5 CHO cell lines growing at different proliferation rates. The goal was to identify microRNAs that correlate positively or negatively with CHO proliferation rates. A common reference design was chosen, where all samples were hybridized against a pool of a...
ORGANISM(S): Cricetulus griseus 
2014-01-07 | E-GEOD-52994 | biostudies-arrayexpress
TranscriptomicsAnalysis of mature miRNA levels in the context of CHO cell proliferation
Mature microRNA transcripts were analyzed in 9 CHO cell lines growing at different proliferation rates. The goal was to identify microRNAs that correlate positively or negatively with CHO proliferation rates. A common reference design was chosen, where all samples were hybridized against a pool of a...
ORGANISM(S): Cricetulus griseus 
2015-12-10 | E-GEOD-75830 | biostudies-arrayexpress
TranscriptomicsProfiling miRNAs of high, low and non-producing CHO cells during biphasic Fed-Batch cultivations reveal interesting targets for cell line engineering
Fed-batch cultivation of recombinant Chinese hamster ovary (CHO) cell lines is one of the most widely used production mode for commercial manufacturing of recombinant protein therapeutics. Furthermore, fed-batch cultivations are often conducted as biphasic processes where culture temperature is decr...
ORGANISM(S): Cricetulus griseus 
2016-04-03 | E-GEOD-72945 | biostudies-arrayexpress
ProteomicsChinese Hamster Ovary cell proteins co-purified with recombinant HIV-1 envelopes, part 3
Chinese Hamster Ovary (CHO) cells are frequently used to produce recombinant HIV envelope protein gp120. In this study, we characterized the CHO proteins that become co-purified with gp120 when lectin affinity chromatography is used. Many of co-purified CHO proteins identified were extracellular m...
ORGANISM(S): Cricetulus Griseus (ncbitaxon:10029) 
2018-02-14 | MSV000082065 | MassIVE
ProteomicsChinese Hamster Ovary cell proteins co-purified with recombinant HIV-1 envelopes, part 2
Chinese Hamster Ovary (CHO) cells are frequently used to produce recombinant HIV envelope protein gp120. In this study, we characterized the CHO proteins that become co-purified with gp120 when lectin affinity chromatography is used. Many of co-purified CHO proteins identified were extracellular m...
ORGANISM(S): Cricetulus Griseus (ncbitaxon:10029) 
2018-01-25 | MSV000081975 | MassIVE
ProteomicsChinese Hamster Ovary cell proteins co-purified with recombinant HIV-1 envelopes, part 4
Chinese Hamster Ovary (CHO) cells are frequently used to produce recombinant HIV envelope protein gp120. In this study, we characterized the CHO proteins that become co-purified with gp120 when lectin affinity chromatography is used. Many of co-purified CHO proteins identified were extracellular m...
ORGANISM(S): Cricetulus Griseus (ncbitaxon:10029) 
2018-01-25 | MSV000081976 | MassIVE
ProteomicsChinese Hamster Ovary cell proteins co-purified with recombinant HIV-1 envelopes, part 1
Chinese Hamster Ovary (CHO) cells are frequently used to produce recombinant HIV envelope protein gp120. In this study, we characterized the CHO proteins that become co-purified with gp120 when lectin affinity chromatography is used. Many of co-purified CHO proteins identified were extracellular m...
ORGANISM(S): Cricetulus Griseus (ncbitaxon:10029) 
2018-01-25 | MSV000081974 | MassIVE
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