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ProteomicsAnalysis of IgG1 producing CHO cells
The effects of changes in bioprocessing parameters (temp, pH, DO) on anti-IL8 IgG1 producing Chinese hamster ovary (CHO) cells were studied on the level of host cell proteome expression using TMT-SPS-MS3.
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2021-04-09 | PXD017779 | Pride
Sps-ms3 Tmt Cho 
ProteomicsProteomics in biomanufacturing control: Protein dynamics of CHO-K1 cells and conditioned media during apoptosis and necrosis
Cell viability has a critical impact on product quantity and quality during the biomanufacturing of therapeutic proteins. An advanced understanding of changes in the cellular and conditioned media proteomes upon cell stress and death is therefore needed for improved bioprocess control. Here, a high ...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2018-02-27 | PXD008297 | Pride
Proteomics Cho Keywords: biomanufacturing Necrosis Apoptosis 2d-lc-mse 
UnknownSteric and not structure-specific factors dictate the endocytic mechanism of glycosylphosphatidylinositol-anchored proteins
Not available
S-JCBD-200903102 | bioimages
UnknownSWOG S0221: a phase III trial comparing chemotherapy schedules in high-risk early-stage breast cancer.
Not available
S-EPMC4268253 | biostudies-literature
MetabolomicsSmall intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders
Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an o...
2019-04-30 | MTBLS876 | MetaboLights
UnknownDose-painting multicenter phase III trial in newly diagnosed glioblastoma: the SPECTRO-GLIO trial comparing arm A standard radiochemotherapy to arm B radiochemotherapy with simultaneous integrated boost guided by MR spectroscopic imaging.
Not available
S-EPMC6385401 | biostudies-literature
ProteomicsA multi-parameter optimization in middle-down analysis of monoclonal antibodies by LC-MS/MS
In antibody-based drug research, regulatory agencies request a complete characterization of antibody proteoforms covering both the amino acid sequence and all post-translational modifications. The usual mass spectrometry-based approach to achieve this goal is bottom-up proteomics, which relies on th...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD038619 | Pride
Orbitrap ms Middle-down proteomics Monoclonal antibody Intact proteins Lc-ms/ms 
ProteomicsDIA based HCP detection in protein A purified IgG1
Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data independent acquisition LC-MS/MS
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2021-05-26 | PXD020127 | Pride
Data independent acquisition (data independent acquisition (dia) Host cell proteins (hcps) Liquid chromatography mass spectrometry Chinese hamster ovary cells (cho)dia) Critical quality attributes (cqa) Monoclonal antibody (mab) Chinese hamster ovary cells (cho) 
ProteomicsVestibular schwannoma is comprised of neural crest and immune subgroups
Vestibular schwannomas (VS) are tumors arising from cranial nerve Schwann cells that cause significant morbidity and are treated with surgery and irradiation. We describe a DNA methylation-based classification of VS into neural crest and immune enriched subgroups and validate our findings using bulk...
ORGANISM(S): Homo Sapiens 
PXD014883 | panorama
TranscriptomicsA small molecule accelerates neuronal differentiation in the adult rat
Adult neurogenesis occurs in mammals and provides a mechanism for continuous neural plasticity in the brain.However, little is known about the molecular mechanisms regulating hippocampal neural progenitor cells (NPCs) and whether their fate can be pharmacologically modulated to improve neural plasti...
ORGANISM(S): Rattus norvegicus 
2010-08-18 | E-GEOD-23668 | biostudies-arrayexpress
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