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ProteomicsPrimary Cilia-Mediated Regulation of Microglial Secretion in Alzheimer's Disease
Proteomic approaches revealed that primary cilia, small hair-like structures found on cells, played a role in the regulation of microglial secretory function. Notably, primary cilia were transiently observed in less than 10% of microglia, and their presence was significantly reduced in microglia fro...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043328 | Pride
Microglia Primary cilia Alzheimer's disease 
ProteomicsExtracellular vesicle-associated proteomic changes from autism patients before and after metabolic stimulation with long-term L-serine treatment
The oral medication of L-serine decreased clinical global impression-severity (CGI-S) and clinical global impression-improvement (CGI-I). Behavioral scores, including communication, daily living skills, socialization, and adaptive behavior composite standardized scores, were estimated by distributio...
ORGANISM(S): Homo sapiens (Human) 
2025-10-23 | PXD042314 | Pride
Autism spectrum disorder Plasma extracellular vesicles L-serine 
ProteomicsA zwitterionic detergent and catalyst-based single-cell proteomics using a loss-free microhole-collection disc
Recent advances in single-cell proteomics have solved many bottlenecks, such as throughput, sample recovery, and scalability via nano-scale sample handling. In this study, we aimed for a sensitive mass spectrometry analysis capable of handling single cells with a conventional mass spectrometry workf...
ORGANISM(S): Homo sapiens (Human) 
2025-05-28 | PXD048052 | Pride
Zwitterionic detergent Tandem mass tags Quadrol Single-cell proteomics 
ProteomicsBrain heterotopia formation by ciliopathic breakdown of neuroepithelial and blood-cerebrospinal fluid barriers
In this study, we found that ablation of genes encoding ciliary transport proteins such as intraflagellar transport homolog 88 (Ift88) and kinesin family member 3a (Kif3a) in cortical radial progenitors led to periventricular heterotopia during late mouse embryogenesis. Conditional mutation of prima...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-10 | PXD038557 | Pride
Cerebrospinal fluid Lc-msms 
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