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MetabolomicsL-serine enables reducing the virulence of Acinetobacter baumannii and modulating the SIRT1 pathway to eliminate the pathogen

The emergence of high-virulent Acinetobacter baumannii strains increases the mortality of patients and seriously affects their prognosis, which motivates us to explore novel ways to control such infections. In this study, gas chromatography-mass spectrometry was adopted to explore the me...

2024-01-18 | MTBLS8966 | MetaboLights
ProteomicsExtracellular vesicle-associated proteomic changes from autism patients before and after metabolic stimulation with long-term L-serine treatment
The oral medication of L-serine decreased clinical global impression-severity (CGI-S) and clinical global impression-improvement (CGI-I). Behavioral scores, including communication, daily living skills, socialization, and adaptive behavior composite standardized scores, were estimated by distributio...
ORGANISM(S): Homo sapiens (Human) 
2025-10-23 | PXD042314 | Pride
Autism spectrum disorder Plasma extracellular vesicles L-serine 
GenomicsSLC38A2 mediates selective L-serine influx across the blood-brain barrier and controls brain D-serine and excitatory synapse development
SLC38A2 mediates selective L-serine influx across the blood-brain barrier and controls brain D-serine and excitatory synapse development
PRJNA1462775 | ENA
TranscriptomicsExpression data from parental MDA-MB-231 cells and MDA-MB-231(SA) variant
Since bone metastatic breast cancer is an incurable disease, causing significant morbidity and mortality, understanding of the underlying molecular mechanisms would be highly valuable. Here, we describe in vitro and in vivo evidence for the importance of serine biosynthesis in the metastasis of brea...
ORGANISM(S): Homo sapiens 
2010-04-19 | E-GEOD-20085 | biostudies-arrayexpress
TranscriptomicsSLC38A2 mediates selective L-serine influx across the blood-brain barrier and controls brain D-serine and excitatory synapse development
L-Serine is essential for brain metabolism, serving as a precursor for the synthesis of the neuromodulator D-serine, glycine, and lipids. Contrary to the prevailing view that brain L-serine is derived exclusively from local synthesis, our findings demonstrate that dietary L-serine is required to mai...
ORGANISM(S): Mus musculus 
2026-08-04 | GSE330116 | GEO
MetabolomicsImpaired Glycolysis-Derived Serine Metabolism as a Key Driver of Podocyte Injury with Senescence

Chronic kidney disease (CKD) is a major health issue, with podocyte injury with senescence playing a central role in glomerulosclerosis. This study investigates the link between glycolysis-derived serine metabolism and podocyte injury with senescence, focusing on the role of phosphoglycerate kina...

2025-08-23 | MTBLS12883 | MetaboLights
GenomicsEubacterium rectale improves the efficacy of anti-PD1 immunotherapy in melanoma via L-serine-mediated NK-cell activation
Eubacterium rectale improves the efficacy of anti-PD1 immunotherapy in melanoma via L-serine-mediated NK-cell activation
PRJNA938040 | ENA
UnknownImproving L-serine formation by Escherichia coli by reduced uptake of produced L-serine.
Not available
S-EPMC7071685 | biostudies-literature
MetabolomicsAssociation Study on the Regulation of Muscle Development-Related Genes, Proteins, and Metabolites in Different Parts by Gastrointestinal Flora During Various Developmental Stages of Liaoning Cashmere Goats

Introduction: Muscle growth and development in Liaoning cashmere goats (a dual-purpose breed for cashmere and meat) and its regulation by intestinal flora are key to improving meat production, yet relevant molecular mechanisms remain unclear.

Objectives: To reveal the molecular mechanism ...

2025-10-30 | MTBLS12972 | MetaboLights
TranscriptomicsTranscription profiling of E. coli MG1655 treated with serine hydroxamate
For over 30 years, serine hydroxamate has been used to chemically stimulate a stringent response in Escherichia coli and other bacteria. These studies have elucidated numerous characteristics of the classical stringent response beyond the simple cellular response to an amino acid shortage, including...
ORGANISM(S): Escherichia coli 
2009-08-25 | E-GEOD-17506 | biostudies-arrayexpress
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