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MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
ModelsBenson2017 - Systems Pharmacology Multidrug (cholesterol biosynthesis pathway)
BensonWattersonetal_SystemsPharmacology_Multidrug This model is described in the article: Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway. Benson H, Watterson S, Sharman J, Mpamhanga C, Parton A, Southan C, Ha...
2017-09-26 | MODEL1506220000 | BioModels
ModelsCholesterol Regulatory Pathway
BACKGROUND: Qualitative dynamics of small gene regulatory networks have been studied in quite some details both with synchronous and asynchronous analysis. However, both methods have their drawbacks: synchronous analysis leads to spurious attractors and asynchronous analysis lacks computational effi...
2172 | Cell Collective
ModelsMazein2013 - Cholesterol biosynthesis pathway
No description
2015-04-15 | MODEL1409170000 | BioModels
TranscriptomicsPeturbation of PICALM Levels Alters Cellular Cholesterol Metabolism
PICALM (Phosphatidyl Inositol Clathrin Assembly Lymphoid Myeloid protein) is a ubiquitously expressed protein that plays a role in clathrin-mediated endocytosis. PICALM also affects the internalization of SNAREs and modulates macroautophagy. Chromosomal translocations that result in the fusion of PI...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-64855 | biostudies-arrayexpress
MetabolomicsCroquemort elicits activation of the immune deficiency pathway in ticks
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain e...
2023-04-27 | MTBLS686 | MetaboLights
ProteomicsAn environmentally relevant mixture of organophosphate esters induces cholesterol biosynthesis in THP-1 macrophages
Organophosphate esters (OPEs), widely used as flame retardants and plasticizers, are environmental toxicants known to disrupt lipid metabolism. Although most studies have focused on individual OPEs, environmental exposures typically involve complex mixtures. Our previous studies demonstrated that a ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067007 | Pride
Macrophage Flame retardants Organophosphate esters Mixture Lipid droplets Cholesterol biosynthesis Proteomics 
MetabolomicsTranscriptome and Metabolome Analyses Reveal Differences in Terpenoid and Flavonoid Biosynthesis in Cryptomeria fortunei Needles Across Different Seasons

Cryptomeria fortunei (Chinese cedar) has outstanding medicinal value due to its abundant flavonoid and terpenoid contents. The metabolite contents of C. fortunei needles differ across different seasons. However, the biosynthetic mechanism of these differentially synthesized meta...

2022-08-12 | MTBLS4099 | MetaboLights
TranscriptomicsEffect of dietary fat and cholesterol on hepatic gene expression of liver-specific Cyp51 knockout male and female mice
Cholesterol is one of the key molecules in mammals and the most striking examples of its deficiency are the inborn errors of cholesterol biosynthesis that manifest in severe whole body phenotypes. Liver, the principal site of cholesterol homeostasis, has rarely been investigated in these defects. We...
ORGANISM(S): Mus musculus 
2015-05-28 | E-GEOD-58271 | biostudies-arrayexpress
ProteomicsViperin inhibits cholesterol biosynthesis and interacts with enzymes in the cholesterol biosynthetic pathway
Many enveloped viruses bud from cholesterol-rich lipid rafts on the cell membrane. Depleting cellular cholesterol impedes this process and results in viral particles with reduced viability. Viperin (virus inhibitory protein endoplasmic reticulum-associated, interferon-induced) is an ER membrane-as...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023999 | Pride
Viperin  cholesterol regulation  interactome analysis  radical sam enzyme  squalene monooxygenase  lanosterol synthase 
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