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MetabolomicsNMR analysis of Synthetic Mixture Analysis
Not available
ORGANISM(S): - 
ST000101 | MetabolomicsWorkbench
MetabolomicsBisphenol mixture-induced DGKB downregulation promotes premature human neurogenesis through the activation of MAPK pathway

The widespread industrial transition from bisphenol A (BPA) to structural analogs such as BPS, BPE, and BPAF has raised significant concerns regarding their potential health risks. However, their neurodevelopmental risks and underlying molecular mechanisms, particularly when present as complex m...

2026-09-29 | MTBLS15671 | MetaboLights
MetabolomicsReal-world neonicotinoid mixture exposure reveals synergistic cytotoxicity and divergent pathway vulnerabilities in human cell lines

In this study, five human cell lines (A2780, Chang liver, HEK293T, HeLa, and HepG2) were used as models and exposed to mixtures of neonicotinoids (NEOs) and their metabolites. The mixture concentrations were prepared based on human biomonitoring data to reflect the actual detected levels of NEOs ...

2026-06-22 | MTBLS13896 | MetaboLights
MetabolomicsMulti-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats
Health effects of pesticides are not always accurately detected using the current battery of regulatory toxicity tests. We compared standard histopathology and serum biochemistry measures and multi-omics analyses in a subchronic toxicity test of a mixture of six pesticides frequently detected in foo...
2020-11-19 | MTBLS138 | MetaboLights
MetabolomicsMetaboKit: a comprehensive data extraction tool for untargeted metabolomics (Standard mixture assay)

We have developed MetaboKit, a comprehensive software package for compound identification and relative quantification in mass spectrometry-based untargeted metabolomics analysis. In data dependent acquisition (DDA) analysis, MetaboKit constructs a customized spectral library with compound identit...

2021-11-05 | MTBLS1311 | MetaboLights
MetabolomicsToxicokinetics and Metabolomic Disrupting of the Flame Retardant Mixture Firemaster 550
Not available
ORGANISM(S): Rattus norvegicus 
ST000415 | MetabolomicsWorkbench
MetabolomicsComparison of Metabolites Variation and Antiobesity Effects of a Mixture of Cudrania tricuspidata, Lonicera caerulea, and the Soybean According to Fermentation in vitro and in vivo
Not available
ORGANISM(S): Mus musculus 
ST000316 | MetabolomicsWorkbench
TranscriptomicsToxicogenomic responses in rainbow trout hepatocytes exposed to model chemicals and a synthetic mixture
Comparison of gene expression of exposed versus non-exposed Oncorhynchus mykiss hepatocytes to four model chemicals and a synthetic mixture. Hepatocytes were exposed for 24 hours to a single chemical and a synthetic mixture of 10 nM 17 alpha-ethinylestradiol (EE2), 0.75 nM 2,3,7,8-tetrachloro-di-be...
ORGANISM(S): Oncorhynchus mykiss 
2010-06-05 | E-GEOD-6416 | biostudies-arrayexpress
ProteomicsStadard peptide mixture plus HeLa
To test our peak detection and label-free quantitation algorithm, practical applications of AB3D for LC-MS data sets were evaluated using a standard peptide mixture consisting of bovine serum albumin (BSA) peptides with different concentrations, peptides derived from four standard proteins (data ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2014-12-04 | PXD001259 | Pride
Lc-ms Peptide mixture 
ProteomicsAn environmentally relevant mixture of organophosphate esters induces cholesterol biosynthesis in THP-1 macrophages
Organophosphate esters (OPEs), widely used as flame retardants and plasticizers, are environmental toxicants known to disrupt lipid metabolism. Although most studies have focused on individual OPEs, environmental exposures typically involve complex mixtures. Our previous studies demonstrated that a ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067007 | Pride
Macrophage Flame retardants Organophosphate esters Mixture Lipid droplets Cholesterol biosynthesis Proteomics 
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