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TranscriptomicsDietary folate depletion and repletion in C57BL/6J mice, ApoE knockout mice, and choline supplemented C57BL/6J mice
Defects in homocysteine and folate metabolism are associated with increased risks for neural tube and congenital heart defects, cardiovascular disease and stroke, cancers, and neurodegeneration. In many but not all cases, dietary supplementation with folate significantly reduces the severity and in...
ORGANISM(S): Mus musculus 
2008-08-27 | E-GEOD-9243 | biostudies-arrayexpress
TranscriptomicsDietary folate depletion and repletion
This SuperSeries is composed of the following subset Series: GSE9242: Dietary folate depletion and repletion in A/J and C57BL/6J mice GSE9243: Dietary folate depletion and repletion in C57BL/6J mice, ApoE knockout mice, and choline supplemented C57BL/6J mice Keywords: SuperSeries Refer to individual...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-9245 | biostudies-arrayexpress
ProteomicsAP2-HS and a GDV1 regulatory feedback loop mediate environmental induction of sexual conversion in Plasmodium falciparum
Transmission of Plasmodium spp. from a human host to a mosquito vector requires that some parasites abandon the asexual replicative cycle in the blood, associated with all clinical symptoms of malaria, and convert into non-replicative sexual precursors called gametocytes. The sexual conversion rate ...
ORGANISM(S): Plasmodium falciparum 
2026-07-28 | PXD064373 | Pride
Plasmodium falciparum Dha Sexual conversion Choline-depletion 
UnknownThe transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet.
Not available
S-EPMC3991247 | biostudies-literature
GenomicsMus musculus
Dietary folate depletion and repletion in C57BL/6J mice, ApoE knockout mice, and choline supplemented C57BL/6J mice
PRJNA105255 | ENA
TranscriptomicsMetabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption
Abstract: Choline is an essential nutrient and methyl donor required for epigenetic regulation. Here, we assess the impact of gut microbial choline metabolism on bacterial fitness and host biology by engineering a microbial community to lack a single choline-utilizing enzyme. Our results indicate th...
ORGANISM(S): Mus musculus 
2017-07-28 | GSE100983 | GEO
TranscriptomicsWhole body Knockout of PC-TP (Pctp-/-), Hepatic whole RNAseq comparing Wild Type (WT) and knock out mic (KO) as well as Chow Fed and Methionine and choline depleted (MCD) fed mice.
Previous studies have used this model to show that PC-TP has a protective effect when challenged with a methionine and choline depleted diet, known to induce NAFLD. We performed transcription factor binding experiments and show that PPARs are dysregulated in the contect of PC-TP depletion We then pe...
ORGANISM(S): Mus musculus 
2023-02-12 | GSE224877 | GEO
MetabolomicsTranscriptomic and Metabolomics Profiling of Phage–Host Interactions between Phage PaP1 and Pseudomonas aeruginosa
The basic biology of bacteriophage–host interactions has attracted increasing attention due to a renewed interest in the therapeutic potential of bacteriophages. In addition, knowledge of the host pathways inhibited by phage may provide clues to novel drug targets. However, the effect of phage on ba...
2018-05-03 | MTBLS431 | MetaboLights
UnknownMetabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline.
Not available
S-EPMC2909293 | biostudies-literature
MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
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