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TranscriptomicsDo different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons
The complexity of events associated with age-related memory loss (ARML) cannot be overestimated. The problem is further complicated by the enormous diversity of neurons in the CNS and even synapses of one neuron within a neural circuit. Large-scale single-neuron analysis is not only challenging but ...
ORGANISM(S): Aplysia californica 
2010-05-20 | E-GEOD-18783 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression analysis of human fibroblasts and converted neurons
Human fibroblasts can be directly converted into cholinergic neurons by Neurogenin 2 (Neurog2 or NGN2) under the treatments of small molecules. Genome-wide analysis of gene expression was performed to examine the similarity of converted neurons to samples from human brain or spinal cord. Total RNA o...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-45954 | biostudies-arrayexpress
GenomicsSTAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex
The motor neuron (MN)–hexamer complex consisting of LIM homeobox 3, Islet-1, and nuclear LIM interactor is a key determinant of motor neuron specification and differentiation. To gain insights into the transcriptional network in motor neuron development, we performed a genome-wide ChIP-sequencing an...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-50993 | biostudies-arrayexpress
GenomicsCholinergic neuron-to-glioblastoma synapses in a human iPSC-derived co-culture model
Cholinergic neuron-to-glioblastoma synapses in a human iPSC-derived co-culture model
PRJNA1251540 | ENA
TranscriptomicsAge-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia
Despite the advances in our understanding of aging-associated behavioral decline, we know relatively little about how aging affect neural circuits that underlie specific behaviors. Specifically, we know little about how aging affect expression of genes in specific neural circuits. We have now addres...
ORGANISM(S): Aplysia californica 
2014-02-05 | E-GEOD-46618 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cholinergic SN56.B5.G4 cells treated with beta-amyloid or hydrogen peroxide
Effect of beta-Amyloid and oxidative stress on gene expression in cholinergic SN56.B5.G4-cells
ORGANISM(S): Mus musculus 
2005-01-01 | E-MEXP-710 | biostudies-arrayexpress
GenomicsA role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration [timecourse]
A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration [timecourse]
PRJNA1264050 | ENA
GenomicsA role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration [Bmal1-KO]
A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration [Bmal1-KO]
PRJNA1264061 | ENA
TranscriptomicsCholinergic neuron-to-glioblastoma synapses in a human iPSC-derived co-culture model
This study examines a co-culture model of human iPSC-derived cholinergic neurons with glioblastoma (GBM) cells derived from GBM organoids (GBOs; UP-10072). To examine transcriptional regulation of GBM cells by cholinergic neurons, we performed scRNAseq of a set of distinct conditions: 1) cholinergic...
ORGANISM(S): Homo sapiens 
2025-05-17 | GSE294747 | GEO
GenomicsSingle nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
PRJNA705097 | ENA
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