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TranscriptomicsT (Brachyury) gene duplication confers major susceptibility to familial chordoma
Using high-resolution array-CGH, we identified unique duplications of a region on 6q27 in four multiplex (≥ with ≥ 3 cases) families of chordoma, a cancer of presumed notochordal origin. comparison of test samples from chordoma families to a reference DNA sample
ORGANISM(S): Homo sapiens 
2009-10-04 | E-GEOD-17668 | biostudies-arrayexpress
TranscriptomicsA common single nucleotide variant in T is strongly associated with chordoma
Gene expression profile of human chordoma samples. These samples were combined with the chordoma samples from those of E-MEXP-353. These were normalised and batch corrected as per materials and methods in the published paper. Gene set enrichment analysis was then performed to determine enrichment o...
ORGANISM(S): Homo sapiens 
2013-08-20 | E-MEXP-3717 | biostudies-arrayexpress
ProteomicsClinical-proteomic classification and precision treatment strategy of chordoma
Clinical-proteomic classification and precision treatment strategy of chordoma
ORGANISM(S): Homo Sapiens 
PXD053631 |
ProteomicsHuman skull base chordoma LC-MSMS
The prognostic factors of skull base chordoma associated with outcomes of patients after surgical resection remain poorly defined. This project aimed to identify a novel prognostic factor for patients with skull base chordoma. Using a proteomics approach, we screened tumor biomarkersthat upregulated...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025894 | Pride
Human Lc-msms Skull base chordoma 
TranscriptomicsA novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-kB signaling in chordoma biology [SNP array]
Chordoma is a rare primary bone malignancy that arises in the skull base, spine and sacrum and originates from remnants of the notochord. These tumors are typically resistant to conventional chemotherapy, and to date there are no FDA-approved agents to treat chordoma. The lack of in vivo models of c...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-50136 | biostudies-arrayexpress
TranscriptomicsChordoma Cell Lines Characterization
mRNA Expression of established chordoma cell lines for characterization. Comparative analysis
ORGANISM(S): Homo sapiens 
2015-05-05 | E-GEOD-68497 | biostudies-arrayexpress
TranscriptomicsChordoma_32k_1Mb
Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridization DNA copy number analysis of 21 fresh frozen chordoma biopsies, and the respective relapse in four of them, using 32k and 1Mb array CGH. All cases showed copy number al...
ORGANISM(S): Homo sapiens 
2008-01-24 | E-GEOD-9023 | biostudies-arrayexpress
TranscriptomicsArrayCGH study to investigate duplication of T locus in chordoma
Duplication of T is a known familial susceptibility determinant for chordoma. TO determine if a similar genetic alteration occurs in the sporadic disease a high-resolution array-CGH (Agilent custom-designed arrayCGH chip) was used to interrogate the chr 6q27 locus for duplication of T. Twenty two sa...
ORGANISM(S): Homo sapiens 
2012-10-04 | E-MEXP-3753 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP 6.0 array data for chordoma samples
Chordomas are rare, low to intermediate grade malignant bone tumors of the axial skeleton, believed to originate from the notochord. Treatment options are limited and mainly restricted to surgical excision, as chordomas have been proven to be largely resistant to conventional ionizing radiation and ...
ORGANISM(S): Homo sapiens 
2012-07-11 | E-GEOD-25720 | biostudies-arrayexpress
UnknownMolecular characterization of putative chordoma cell lines.
Not available
S-EPMC3022207 | biostudies-literature
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