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MetabolomicsLow chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights
TranscriptomicsArray-based DNA-methylation profiling of fetal tissues obtained by routine invasive prenatal testing (chorionic and amniotic samples)
Genome wide DNA methylation profiling of fetal DNA-methylation levels in 47 chorionic villi (CVS) and 16 amniotic cell (AC) samples. The Illumina Infinium 27k Human DNA methylation Beadchip was used to determine DNA methylation profiles across approximately 27,578 CpGs in fetal samples. Bisulphite c...
ORGANISM(S): Homo sapiens 
2012-12-14 | E-GEOD-35327 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human chorionic villi cells co-culutured with fetal cardiomyocytes
In the chorionic villi of placenta, trophoblasts and endothelial cells are present, and moreover mesenchymal cells (stromal cells) can be obtained. We generated cells with the mesenchymal phenotype from the chorionic mesoderm, and showed that: a) physiologically functioning cardiomyocytes were trans...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7021 | biostudies-arrayexpress
ProteomicsComparative proteomics analysis of chorionic villi in recurrent pregnancy loss
The project aimed to determine proteomics changes in chorionic villi from patients suffering from unexplained early recurrent pregnancy loss (RPL) compared to women undergoing elective abortions. Comparative proteomics analysis by label-free data-independent LC-MS/MS was performed on fresh frozen ch...
ORGANISM(S): Homo sapiens (Human) 
2024-08-27 | PXD048344 | Pride
Human Recurrent pregnancy loss Rapigest Progenesis qip Chorionic villi Biomarker Lc-ms/ms 
TranscriptomicsTranscriptomic profile of human placenta derived trophoblast organoid cultures with its tissue of origin, human placental villi.
The aim of this microarray experiment was to compare the overall transcriptomic profile of human placenta derived trophoblast organoid cultures with its tissue of origin, human placental villi. As the placental villi contains both trophoblast and stromal populations, we have included placenta derive...
ORGANISM(S): Homo sapiens 
2018-11-28 | E-MTAB-6683 | biostudies-arrayexpress
TranscriptomicsChorionic villi cells
In the chorionic villi of placenta, trophoblasts and endothelial cells are present, and moreover mesenchymal cells (stromal cells) can be obtained. We generated cells with the mesenchymal phenotype from the chorionic mesoderm, and showed that: a) physiologically functioning cardiomyocytes were trans...
ORGANISM(S): Homo sapiens 
2007-02-17 | GSE7021 | GEO
GenomicsInvestigating Human Placentation and Pregnancy Using First Trimester Chorionic Villi
Investigating Human Placentation and Pregnancy Using First Trimester Chorionic Villi
PRJNA377795 | ENA
GenomicsCharacteristic DNA methylation profiles of chorionic villi in recurrent miscarriage
Characteristic DNA methylation profiles of chorionic villi in recurrent miscarriage
PRJNA816500 | ENA
ProteomicsHuman chorionic villus proteome
We evaluated the effect of the different solubilization techniques on the reproducibility and width of the chorionic proteome characterized using bottom-up proteomics: SDS-based solubilization coupled with in-gel protein digestion after applying self-named 1DE gel-concentration procedure (SDS-PAGE w...
ORGANISM(S): Homo sapiens (Human) 
2022-06-17 | PXD024759 | Pride
Human Chorionic villus Trophoblast Lc-ms/ms 
GenomicsHomo sapiens
Chorionic villi cells
PRJNA98369 | ENA
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