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TranscriptomicsTranscription profiling of human donor-matched retinal and choroidal vascular endothelial cells
Consistent with clinical observations that posterior uveitis frequently involves the retinal vasculature and recent recognition of vascular heterogeneity, we hypothesized that retinal vascular endothelium was a cell population of unique molecular phenotype. Donor-matched cultures of primary retinal ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7850 | biostudies-arrayexpress
ProteomicsAngiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Choroidal and Retinal Vascular Endothelial Cells
PURPOSE Diseases that involve choroidal or retinal endothelial vascular cells are leading causes of vision loss: age-related macular degeneration, retinal ischemic vasculopathies and non-infectious posterior uveitis. Proteins differentially expressed by these endothelial cell populations are potenti...
ORGANISM(S): Homo sapiens (Human) 
2018-03-26 | PXD005972 | Pride
Protein expression Mudpit Tandem mass spectrometry Human Cell culture Endothelial cells Proteomics Choroid Linear ion trap Spectral counting Retina 
ProteomicsLysosomal channel TPC2 modulates microglia-endothelial signaling in choroidal angiogenesis
Pathological choroidal neovascularization underlies vision loss in neovascular age-related macular degeneration (nAMD), yet the molecular regulators coordinating vascular and immune components remain incompletely defined. Here, we investigated the role of the endolysosomal cation channel, two-pore c...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD081711 | Pride
Choroidal vascular cell 
TranscriptomicsRegional difference in gene expression of proliferating human choroidal endothelial cells
To investigate the differences in gene expression between matched human macular and peripheral choroidal endothelial cells (CEC) and matched human macular inner and outer CEC. The gene expression profiles of the unpassaged cell types were compared using Affymetrix GeneChip arrays. 9 arrays are inclu...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-51246 | biostudies-arrayexpress
TranscriptomicsComparative Gene Expression Profiling of HUVEC and Ocular Vascular Endothelial Cells
To compare the gene expression profiles of unpassaged, proliferating HUVEC and human iris, retinal and choroidal microvascular endothelial cells. Gene expression profiling revealed significant differences between HUVEC and ocular microvascular endothelial cells suggesting that HUVE cells may not be ...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-20986 | biostudies-arrayexpress
ProteomicsLysosomal channel TPC2 modulates microglia-endothelial signaling in choroidal angiogenesis
Pathological choroidal neovascularization underlies vision loss in neovascular age-related macular degeneration (nAMD), yet the molecular regulators coordinating vascular and immune components remain incompletely defined. Here, we investigated the role of the endolysosomal cation channel, two-pore c...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD081654 | Pride
Retinal microglia 
TranscriptomicsEndothelial cell heterogeneity in pathological angiogenesis characterized by metabolic transcriptome diversity
Endothelial cell (EC) metabolism regulates angiogenesis and is an emerging target for anti-angiogenic therapy in tumor and choroidal neovascularization (CNV). In contrast to tumor ECs (TECs), CNV-ECs cannot be isolated for unbiased metabolic target discovery. Here we used scRNA-sequencing to profile...
ORGANISM(S): Mus musculus 
2020-06-25 | E-MTAB-8119 | biostudies-arrayexpress
GenomicsVascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation
Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation
PRJNA1309089 | ENA
TranscriptomicsTranscriptome sequencing to identify transcription factor regulatory network and alternative splicing in endothelial cells under VEGF stimulation
Human umbilical vein vascular endothelial cells (HUVECs) are crucial for angiogenesis that benefits functional recovery after cerebral infarction. This study aims to investigate the mechanisms underlying the effects of vascular endothelial growth factor (VEGF) on HUVECs. HUVECs were treated with 16 ...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71216 | biostudies-arrayexpress
TranscriptomicsUnique Gene Expression Profiles of Donor-Matched Human Retinal and Choroidal Vascular Endothelial Cells
Consistent with clinical observations that posterior uveitis frequently involves the retinal vasculature and recent recognition of vascular heterogeneity, we hypothesized that retinal vascular endothelium was a cell population of unique molecular phenotype. Donor-matched cultures of primary retinal ...
ORGANISM(S): Homo sapiens 
2007-05-25 | GSE7850 | GEO
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