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MetabolomicsThe Carbohydrate Sensing Transcription Factor ChREBP Links Mitochondrial Lipidomes to Mitochondrial Dynamics and Progression of Diabetic Nephropathy
Not available
ORGANISM(S): Mus musculus 
ST002145 | MetabolomicsWorkbench
ProteomicsLC-MS/MS Data for Identification of ChREBP O-GlcNAcylation
LC-MS/MS analysis of O-GlcNAcylated ChREBP proteins, which were overexpressed in HEK293T cells and purified via affinity purification using Ni-NTA agarose
ORGANISM(S): Mus musculus (Mouse) 
2017-05-04 | PXD004286 | Pride
Mouse O-glcnac Chrebp Lc-ms/ms 
ProteomicsProline hydroxylation of ChREBP
This project investigated proline hydroxylation of ChREBP. Proline hydroxylation was investigated in flag-IP enriched protein extracts from ChREBP-flag overexpressing HEK293 cells (A) and in ChREBP-IP enriched mouse liver protein (male, C57BL6/J) (B).
ORGANISM(S): Mus musculus (Mouse) 
2020-10-19 | PXD019137 | Pride
Hek293 Mouse liver Proline hydroxylation 
TranscriptomicsHNF1-alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP1 & ChREBP activation
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1a (HNF1a), were identified in 50% of hepatocellular adenomas (HCA) phenotypically characterized by a striking steatosis. To understand the molecular basis of this aberrant lipid storage, w...
ORGANISM(S): Homo sapiens 
2007-05-01 | E-GEOD-7473 | biostudies-arrayexpress
GenomicsIntegrative genomics outlines a biphasic glucose response and a ChREBP-RORγ axis regulating proliferation in β-cells
Glucose is an important regulator of pancreatic β-cell function. In addition to the acute stimulation of insulin secretion, glucose stimulates long-term adaptive changes in gene expression that can either promote or antagonize the proliferative potential and function of β-cells. The glucose-sensin...
ORGANISM(S): Rattus norvegicus 
2016-09-06 | E-GEOD-81628 | biostudies-arrayexpress
TranscriptomicsIntergrated expression profiling and ChIP-SEQ analyses of ChREBP-mediated glucose response network (expression data only)
We identified ChREBP-binding regions from the DNA of human hepatocellular targets as well as previously-known targets Total RNA from hepG2 cell line
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-22074 | biostudies-arrayexpress
GenomicsChREBP ChIP-seq data from primary cultured hepatocytes
ChREBP ChIP-seq data from primary cultured hepatocytes
PRJNA1054069 | ENA
ProteomicsMLX phosphorylation is an evolutionarily conserved mechanism to promote lipid storage and sugar tolerance
To cope with food scarcity, animals store energy as lipids, which are produced from carbohydrates via de novo lipogenesis (DNL). The carbohydrate-responsive ChREBP-MLX complex is a master transcriptional regulator for DNL and lipid storage. However, our understanding of molecular mechanisms, particu...
ORGANISM(S): Homo sapiens (Human) 
2025-03-13 | PXD054667 | Pride
Carbohydrate and lipid metabolism Sugar tolerance Fly development 
GenomicsGene expression altered by Chrebp deficiency and fructose treatment
Gene expression altered by Chrebp deficiency and fructose treatment
PRJNA689855 | ENA
GenomicsExpression data from liver samples overexpressing either GFP or ChREBP
Expression data from liver samples overexpressing either GFP or ChREBP
PRJNA670027 | ENA
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