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GenomicsATRX-mediated chromatin association of histone variant macroH2A1 regulates alpha globin gene expression
The histone variant macroH2A generally associates with transcriptionally inert chromatin, however the factors that regulate its chromatin incorporation remain elusive. Here, we identify the SWI/SNF helicase, ATRX, as a novel macroH2A interacting protein. Unlike its role in assisting H3.3 chromatin d...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-35339 | biostudies-arrayexpress
GenomicsSF3B1 association with chromatin determines splicing outcomes
Much remains unknown concerning the mechanism by which the splicing machinery pinpoints short exons within intronic sequences and how splicing factors are directed to their pre-mRNA targets. Part of the explanation probably lies in differences in chromatin organization between exons and introns. Pro...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-65644 | biostudies-arrayexpress
GenomicsHNF1B chromatin association analysis
HNF1B chromatin association analysis
PRJEB46088 | ENA
GenomicsChromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants (ChIP-seq)
Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcriptome pro- filing in human pancreatic islets. Integra...
ORGANISM(S): Homo sapiens 
2013-11-08 | E-GEOD-51311 | biostudies-arrayexpress
GenomicsGenomic Profiling of HMGN1 Reveals an Association with Chromatin at Regulatory Regions
High mobility group (HMG) proteins interact with other architectural proteins to regulate chromatin structure. We performed genome-wide mapping experiments to examine the distribution of HMGN1 across the human genome. We discovered that HMGN1 proteins are enriched at regulatory regions such as DNas...
ORGANISM(S): Homo sapiens 
2010-11-30 | E-GEOD-25674 | biostudies-arrayexpress
TranscriptomicsPhosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function
Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett Syndrome. As a chromatin associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. While neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been repor...
ORGANISM(S): Mus musculus 
2009-02-10 | E-GEOD-14715 | biostudies-arrayexpress
TranscriptomicsGenomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns
CHD7 is a member of the chromodomain helicase DNA binding domain family of ATP-dependent chromatin remodeling enzymes. De novo mutation of the CHD7 gene is a major cause of CHARGE syndrome, a genetic disease characterized by a complex constellation of birth defects. To gain insight to the function...
ORGANISM(S): Mus musculus 
2009-01-22 | E-GEOD-14460 | biostudies-arrayexpress
GenomicsDynamics of yeast ISWI and CHD chromatin remodeler genomic association (part 1)
Chromatin remodelers influence genetic processes by altering nucleosome occupancy, positioning, and composition. In vitro, yeast ISWI and CHD remodelers require > 20 bp of extranucleosomal DNA for remodeling, but linker DNA in S. cerevisiae averages < 20 bp. To resolve this paradox, we have mapped t...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-01 | E-GEOD-39430 | biostudies-arrayexpress
GenomicsDynamics of yeast ISWI and CHD chromatin remodeler genomic association (part 2)
Chromatin remodelers influence genetic processes by altering nucleosome occupancy, positioning, and composition. In vitro, yeast ISWI and CHD remodelers require > 20 bp of extranucleosomal DNA for remodeling, but linker DNA in S. cerevisiae averages < 20 bp. To resolve this paradox, we have mapped t...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-01 | E-GEOD-39431 | biostudies-arrayexpress
TranscriptomicsMapping and analysis of chromatin state dynamics in nine human cell types (gene expression)
Chromatin profiling has emerged as a powerful means for annotating genomic elements and detecting regulatory activity. Here we generate and analyze a compendium of epigenomic maps for nine chromatin marks across nine cell types, in order to systematically characterize cis-regulatory elements, their ...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-26312 | biostudies-arrayexpress
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