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MetabolomicsPostoperative Metabolic Phenoreversion in Clear Cell Renal Cell Carcinoma

The ultimate goal of surgical treatment in cancer is to remove the tumor mass for restoring a healthy state. A 16-lipid panel that discriminated healthy controls from clear cell renal cell carcinoma (ccRCC) patients in a prior study was evaluated in the present work in paired-serum samples collec...

2023-01-02 | MTBLS3838 | MetaboLights
MetabolomicsMetabolic Footprinting of a Clear Cell Renal Cell Carcinoma in vitro Model for Human Kidney Cancer Detection
A protocol for harvesting and extracting extracellular metabolites from an in vitro model of human renal cell lines was developed to profile the exometabolome by means of a discovery-based metabolomics approach using ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass sp...
2018-11-14 | MTBLS737 | MetaboLights
MetabolomicsUrinary multi-omics reveal non-invasive diagnostic biomarkers in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is the most common kidney malignancy. Yet, no rapid, non-invasive biomarkers are available for diagnosis or screening. Urine represents an ideal analyte matrix due to its accessibility, low invasiveness, longitudinal sampling and the kidney’s central role i...

2026-08-16 | MTBLS12025 | MetaboLights
MetabolomicsTargeted metabolomic profiling of FH-deficient clear cell renal cell carcinoma cells
This study investigated metabolic alterations associated with fumarate hydratase (FH) deficiency in clear cell renal cell carcinoma (ccRCC). Targeted metabolomic analysis was performed in 786-O and RCC4 cells with or without FH knockdown, using three biological replicates per condition. Intracellula...
2026-10-16 | MTBLS15359 | MetaboLights
MetabolomicsUrinary multi-omics reveal non-invasive diagnostic biomarkers in clear cell renal cell carcinoma (Lipidomics)

Clear cell renal cell carcinoma (ccRCC) is the most common kidney malignancy. Yet, no rapid, non-invasive biomarkers are available for diagnosis or screening. Urine represents an ideal analyte matrix due to its accessibility, low invasiveness, longitudinal sampling and the kidney’s central role i...

2026-07-15 | MTBLS14671 | MetaboLights
MetabolomicsMass Spectrometry-Based Metabolic Fingerprinting Contributes to Unveil the Role of RSUME in Renal Cell Carcinoma Cell Metabolism
Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with 50-80% patients exhibiting mutations in the von Hippel-Lindau (VHL) gene. RSUME (RWD domain (termed after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)...
2021-10-06 | MTBLS1935 | MetaboLights
ProteomicsProteome profilling of chromophobe renal cell carcinomas
LC-MS/MS based proteomics study of chromophobe renal cell carcinomas versus the adjacent healthy kidney tissues, nine patients included. The chromophobe renal cell carcinoma cells (UOK276) under different conditions were also analyzed.
ORGANISM(S): Homo sapiens (Human) 
2020-07-23 | PXD019123 | Pride
Chromophobe renal cell carcinomas Proteomics Kidney cancer Proteome 
MetabolomicsCoupled Mass-Spectrometry-Based Lipidomics Machine Learning Approach for Early Detection of Clear Cell Renal Cell Carcinoma

A discovery-based lipid profiling study of serum samples from a cohort that included patients with clear cell Renal Cell Carcinoma (ccRCC) stage I, II, III, and IV (n=112) and controls (n=52) was performed using ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass spec...

2020-11-20 | MTBLS1839 | MetaboLights
MetabolomicsFumarate reprograms the ubiquitinated proteome to confer ferroptosis resistance in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is a kidney malignancy characterized by aberrant lipid accumulation and is intrinsically sensitive to ferroptosis. However, the mechanisms by which ccRCC escapes ferroptotic vulnerability remain poorly understood. Here, we report that fumarate hydratase (FH...

2026-10-16 | MTBLS15364 | MetaboLights
Proteomicsproteome profilling of chromophobe renal cell carcinomas
LC-MS/MS based proteomics study of chromophobe renal cell carcinomas versus the adjacent healthy kidney tissues, ten patients included.
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD010391 | Pride
Chromophobe renal cell carcinomas Proteomics Kidney cancer Proteome 
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