Sort   by:  
 Page size 
MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
ProteomicsChromosome 11-Centric Human Proteome Project
For the analysis of chromosome 11-centric human proteome, we analyzed the human brain hippocampal proteome. The samples from brain tissues were extensively off-gel fractionated by 12 fractions and analyzed by a high resolution mass spectrometer, Orbitrap XL ETD with collision induced dissociation...
ORGANISM(S): Homo sapiens (Human) 
2016-10-10 | PXD000395 | Pride
Offgel fractionation Chromosome 11 Pe fraction Human brain hippocampus tissues 
TranscriptomicsGenomic alterations of chromosome 11 induce transcriptome dysregulation in aggressive and malignant prolactin tumours
This SuperSeries is composed of the following subset Series: GSE22615: Genomic alterations of chromosome 11 induce transcriptomic dysregulation in aggressive and malignant prolactin tumours GSE22812: Transcriptomic dysregulation in aggressive and malignant prolactin tumours Refer to individual Serie...
ORGANISM(S): Homo sapiens 
2011-09-15 | E-GEOD-32191 | biostudies-arrayexpress
TranscriptomicsGenomic alterations of chromosome 11 induce transcriptomic dysregulation in aggressive and malignant prolactin tumours
Pituitary tumors are generally considered as benign. However, many are invasive (45 to 55%) and some are described as aggressive with a high proliferation rate and short post-operative time to recurrence and 0.2% metastasize. The molecular events associated to the progression of the pituitary tumor ...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-22615 | biostudies-arrayexpress
GenomicsOryza sativa Japonica Group
rice chromosome 11 and 12 alternate assembly
PRJNA16949 | ENA
TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
TranscriptomicsChromosome length influences replication-induced topological stress
During chromosome duplication the parental DNA molecule becomes over-wound, or positively supercoiled, in the region ahead of the advancing replication fork. To allow fork progression this superhelical tension has to be removed by topoisomerases, which operate by introducing transient DNA breaks. Po...
ORGANISM(S): Saccharomyces cerevisiae 
2011-02-28 | E-GEOD-26263 | biostudies-arrayexpress
TranscriptomicsMapping barley genes to chromosome arms by transcript profiling of wheat-barley ditelosomic chromosome addition lines
We utilized the Barley1 Affymetrix GeneChip for comparative transcript analysis of Betzes barley, Chinese Spring wheat, and Chinese SpringM-bM-^@M-^SBetzes ditelosomic chromosome addition lines to physically map barley genes to their respective chromosome arm locations. We mapped barley genes to ch...
ORGANISM(S): Triticum aestivum 
2011-11-22 | E-GEOD-33400 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human purified plasma cells (PCs) obtained from 90 newly diagnosed multiple myeloma (MM) reveals a distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma
Background and objective: The chromosome 13 deletion (del(13)) represents one of the most frequent chromosomal alterations in multiple myeloma (MM). del(13) is associated with an unfavorable prognosis, although there is an increasing agreement that its prognostic relevance has to be related to the p...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6365 | biostudies-arrayexpress
GenomicsGenome-Wide Analysis of Host-Chromosome Binding Sites for Epstein-Barr Virus Nuclear Antigen 1 (EBNA1)
The Epstein-Barr Virus (EBV) Nuclear Antigen 1 (EBNA1) protein is required for the establishment of EBV latent infection in proliferating B-lymphocytes. EBNA1 is a multifunctional DNA-binding protein that stimulates DNA replication at the viral origin of plasmid replication (OriP), regulates transc...
ORGANISM(S): Homo sapiens 
2011-07-16 | E-GEOD-30709 | biostudies-arrayexpress
Sort   by:  
 Page size