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TranscriptomicsRelevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia
This SuperSeries is composed of the following subset Series: GSE38611: Relevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (expression) GSE38613: Relevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (SNP) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-38618 | biostudies-arrayexpress
TranscriptomicsThe addition of chromosome 8 leads to characteristic dysregulation of gene expression on all chromosome and transformed-associated phenotypes
To examain effects of trisomy 8 on gene expression in normal human cells, we have employed whole genome microarray expression profiling. To study the effects of aneuploidy in normal human cells, we generated cells which are artificially trisomic chromosome 8 (trisomy 8) using human primary fibroblas...
ORGANISM(S): Homo sapiens 
2011-10-07 | E-GEOD-28076 | biostudies-arrayexpress
TranscriptomicsRelevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (expression)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by chromosomal aberrations of prognostic significance. Recent studies showed that gain of chromosome 2p is a recurrent lesion in CLL. We investigated the 2p gain and its relationship with prognostic biomarkers in ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-38611 | biostudies-arrayexpress
ProteomicsDivergent proteome tolerance against gain and loss of chromosome arms
How aneuploid cells tolerate chromosome arm gains or losses remains an open question. Using an isogenic human lung cell model with either 3p loss or 3q gain, combined with quantitative mass spectrometry and isotopic labeling, we reveal distinct proteostasis mechanisms for gain- and loss-type aneuplo...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD062437 | Pride
Proteostasis  gain and loss  chromosome 3  lung cancer  proteomic buffering : aneuploidy  proteomics  dynamic silac  protein degradation  protein synthesis 
TranscriptomicsRelevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (SNP)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by chromosomal aberrations of prognostic significance. Recent studies showed that gain of chromosome 2p is a recurrent lesion in CLL. We investigated the 2p gain and its relationship with prognostic biomarkers in ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-38613 | biostudies-arrayexpress
ProteomicsChromosome 8 gain drives cancer progression by hijacking the translational regulator 4E-BP1 sensitizing for targeted CDK4/6 inhibition
Chromosome 8 (chr8) gains are common in cancer. However, their potential contribution to tumor heterogeneity is largely unexplored. Ewing sarcoma (EwS) is characterized by pathognomonic FET::ETS fusions but a general paucity of other recurrent somatic mutations that could explain the observed clinic...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-09-22 | PXD065282 | Pride
Chromosome 8 gain 4e-bp1 ewing sarcoma Cdk4/6 inhibitor Chromosome 8 amplification Chromosome 8 copy number variation Eif4ebp1 
GenomicsRAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress
RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress
PRJNA516688 | ENA
TranscriptomicsComparative genomic hybridization of benign epithelial and prostate cancer cell lines derived from the same patient
Copy number alterations in a matched pair of benign epithelial and prostate cancer cell lines derived from the same patient were assessed using array-based comparative genomic hybridisation (aCGH). the cancer cell line showed a gain of chromosome 7, deletion of chromosome 8, gains and losses in chro...
ORGANISM(S): Homo sapiens 
2006-08-04 | E-MEXP-803 | biostudies-arrayexpress
TranscriptomicsRAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress
Aneuploidy, defined as whole chromosome gain or loss, causes cellular stress but, paradoxically, is a frequent occurrence in cancers. Here, we investigate why around 50% of Ewing sarcomas, driven by the EWS-FLI1 fusion oncogene, harbor chromosome 8 gains. Expression of the EWS-FLI1 fusion in primary...
ORGANISM(S): Homo sapiens 
2021-04-22 | GSE125529 | GEO
GenomicsDivergent proteome tolerance against gain and loss of chromosome arms
Divergent proteome tolerance against gain and loss of chromosome arms
PRJNA1245409 | ENA
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