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UnknownThe Chromosome 18 Clinical Resource Center.
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S-EPMC6014460 | biostudies-literature
GenomicsSequence and expression analysis of human chromosome 20 gaps
The finished human genome-assemblies comprise several hundred un-sequenced euchromatic gaps, which may be rich in long polypurine/polypyrimidine stretches. Human chromosome 20 currently has three remaining un-sequenced gaps on its q-arm. All three gaps are within gene-dense regions, or overlap loci ...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-35405 | biostudies-arrayexpress
TranscriptomicsChromosome length influences replication-induced topological stress
During chromosome duplication the parental DNA molecule becomes over-wound, or positively supercoiled, in the region ahead of the advancing replication fork. To allow fork progression this superhelical tension has to be removed by topoisomerases, which operate by introducing transient DNA breaks. Po...
ORGANISM(S): Saccharomyces cerevisiae 
2011-02-28 | E-GEOD-26263 | biostudies-arrayexpress
TranscriptomicsSex-dependent and -independent X-chromosome histone modifications in Drosophila melanogaster
Drosophila X chromosomes are subject to dosage compensation in males and are known to have a specialized chromatin structure in the male soma. We are interested in how specific chromatin structure change contributes to X chromosome hyperactivity and dosage compensation. We have conducted a global a...
ORGANISM(S): Drosophila melanogaster 
2010-01-11 | E-GEOD-15593 | biostudies-arrayexpress
ProteomicsThe de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging
In the era of synthetic biology, design, construction, and utilization of synthetic chromosomes with unique features provide a new strategy to study complex cellular processes such as aging. Herein, we successfully constructed the 884 Kb synXIII of Saccharomyces cerevisiae to investigate replicative...
ORGANISM(S): Saccharomyces Cerevisiae 
2024-10-30 | PXD057330 |
TranscriptomicsMeiotic cohesins modulate chromosome compaction during meiotic prophase in fission yeast
The meiotic cohesin Rec8 is required for the stepwise segregation of chromosomes during the two rounds of meiotic division. By directly measuring chromosome compaction in living cells of the fission yeast Schizosaccharomyces pombe, we found an additional role for the meiotic cohesin in the compactio...
ORGANISM(S): Schizosaccharomyces pombe 
2010-07-01 | E-GEOD-5284 | biostudies-arrayexpress
TranscriptomicsThe addition of chromosome 8 leads to characteristic dysregulation of gene expression on all chromosome and transformed-associated phenotypes
To examain effects of trisomy 8 on gene expression in normal human cells, we have employed whole genome microarray expression profiling. To study the effects of aneuploidy in normal human cells, we generated cells which are artificially trisomic chromosome 8 (trisomy 8) using human primary fibroblas...
ORGANISM(S): Homo sapiens 
2011-10-07 | E-GEOD-28076 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of maize segmental aneuploid to study phenotypic and gene expression changes associated with aneuploidy
ABSTRACT: BACKGROUND: While changes in chromosome number that result in aneuploidy are associated with phenotypic consequences such as Down syndrome and cancer, the molecular causes of specific phenotypes and genome-wide expression changes that occur in aneuploids are still being elucidated. RESULTS...
ORGANISM(S): Zea mays 
2008-06-11 | E-GEOD-10243 | biostudies-arrayexpress
ProteomicsProteomics survey of Streptomyces coelicolor strains with natural gross chromosome change
Streptomyces coelicolor normally produce spores with a relatively high heterogeneity, which will produce genetically heterogeneous sub-populations. These sub-populations often exert massive chromosome amplifications and deletions. Cells with gross chromosomal changes produce an increased diversity o...
ORGANISM(S): Streptomyces coelicolor Bacteria 
2020-05-26 | PXD014413 | Pride
Antibiotics over-production Streptomyces coelicolor Bacteria social behavior Chromosome change Division of labour 
TranscriptomicsDistribution of segmental duplications in the context of higher order chromatin organisation of human chromosome 7
Background Segmental duplications (SDs) are not evenly distributed along chromosomes. The reasons for this biased susceptibility to SD insertion are poorly understood. Accumulation of SDs is associated with increased genomic instability, which can lead to structural variants and genomic disorders su...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-41356 | biostudies-arrayexpress
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